HUP2_PARKE
ID HUP2_PARKE Reviewed; 540 AA.
AC Q39524;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=H(+)/hexose cotransporter 2;
DE AltName: Full=Galactose/H(+) symporter;
GN Name=HUP2;
OS Parachlorella kessleri (Green alga) (Chlorella kessleri).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Parachlorella.
OX NCBI_TaxID=3074;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7870840; DOI=10.1104/pp.107.1.33;
RA Stadler R., Wolf K., Hilgarth C., Tanner W., Sauer N.K.;
RT "Subcellular localization of the inducible Chlorella HUP1 monosaccharide-H+
RT symporter and cloning of a Co-induced galactose-H+ symporter.";
RL Plant Physiol. 107:33-41(1995).
CC -!- FUNCTION: Active uptake of galactose.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X66855; CAA47323.1; -; mRNA.
DR AlphaFoldDB; Q39524; -.
DR SMR; Q39524; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Sugar transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..540
FT /note="H(+)/hexose cotransporter 2"
FT /id="PRO_0000050429"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..326
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..337
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..396
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..435
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..458
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 480..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 540 AA; 58343 MW; 0A3801A33E0BA733 CRC64;
MAGGGPVAST TTNRASQYGY ARGGLNWYIF IVALTAGSGG LLFGYDIGVT GGVTSMPEFL
QKFFPSIYDR TQQPSDSKDP YCTYDDQKLQ LFTSSFFLAG MFVSFFAGSV VRRWGRKPTM
LIASVLFLAG AGLNAGAQDL AMLVIGRVLL GFGVGGGNNA VPLYLSECAP PKYRGGLNMM
FQLAVTIGII VAQLVNYGTQ TMNNGWRLSL GLAGVPAIIL LIGSLLLPET PNSLIERGHR
RRGRAVLARL RRTEAVDTEF EDICAAAEES TRYTLRQSWA ALFSRQYSPM LIVTSLIAML
QQLTGINAIM FYVPVLFSSF GTARHAALLN TVIIGAVNVA ATFVSIFSVD KFGRRGLFLE
GGIQMFIGQV VTAAVLGVEL NKYGTNLPSS TAAGVLVVIC VYVAAFAWSW GPLGWLVPSE
IQTLETRGAG MSMAVIVNFL FSFVIGQAFL SMMCAMRWGV FLFFAGWVVI MTFFVYFCLP
ETKGVPVETV PTMFARHWLW GRVMGEKGRA LVAADEARKA GTVAFKVESG SEDGKPASDQ
