ID   HUP3_PARKE              Reviewed;         534 AA.
AC   Q39525;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=H(+)/hexose cotransporter 3;
GN   Name=HUP3;
OS   Parachlorella kessleri (Green alga) (Chlorella kessleri).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC   Chlorellales; Chlorellaceae; Parachlorella.
OX   NCBI_TaxID=3074;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7870840; DOI=10.1104/pp.107.1.33;
RA   Stadler R., Wolf K., Hilgarth C., Tanner W., Sauer N.K.;
RT   "Subcellular localization of the inducible Chlorella HUP1 monosaccharide-H+
RT   symporter and cloning of a Co-induced galactose-H+ symporter.";
RL   Plant Physiol. 107:33-41(1995).
CC   -!- FUNCTION: Active uptake of hexoses.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; X75440; CAA53192.1; -; mRNA.
DR   PIR; S38435; S38435.
DR   AlphaFoldDB; Q39525; -.
DR   SMR; Q39525; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   CDD; cd17361; MFS_STP; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044778; MFS_STP/MST-like_plant.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR045262; STP/PLT_plant.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   PANTHER; PTHR23500; PTHR23500; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Sugar transport; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..534
FT                   /note="H(+)/hexose cotransporter 3"
FT                   /id="PRO_0000050430"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..86
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..113
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..137
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..173
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        195..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..299
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..322
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        323..328
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        350..352
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        374..394
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        416..433
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        455..456
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        478..534
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   534 AA;  57772 MW;  52E03715F3726017 CRC64;
     MAGGAIVASG GASRSSEYQG GLTAYVLLVA LVAACGGMLL GYDNGVTGGV ASMEQFERKF
     FPDVYEKKQQ IVETSPYCTY DNPKLQLFVS SLFLAGLISC IFSAWITRNW GRKASMGIGG
     IFFIAAGGLV NAFAQDIAML IVGRVLLGFG VGLGSQVVPQ YLSEVAPFSH RGMLNIGYQL
     FVTIGILIAG LVNYGVRNWD NGWRLSLGLA AVPGLILLLG AIVLPESPNF LVEKGRTDQG
     RRILEKLRGT SHVEAEFADI VAAVEIARPI TMRQSWRSLF TRRYMPQLLT SFVIQFFQQF
     TGINAIIFYV PVLFSSLGSA SSAALLNTVV VGAVNVGSTM IAVLLSDKFG RRFLLIEGGI
     TCCLAMLAAG ITLGVEFGQY GTEDLPHPVS AGVLAVICIF IAGFAWSWGP MGWLIPSEIF
     TLETRPAGTA VAVMGNFLFS FVIGQAFVSM LCAMKFGVFL FFAGWLVIMV LCAIFLLPET
     KGVPIERVQA LYARHWFWKK VMGPAAQEII AEDEKRVAAS QAIMKEERIS QTMK