HUR1_YEAST
ID HUR1_YEAST Reviewed; 110 AA.
AC P45820; D6VTY4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Putative uncharacterized protein HUR1;
GN Name=HUR1; OrderedLocusNames=YGL168W; ORFNames=G1663;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8896267;
RX DOI=10.1002/(sici)1097-0061(199609)12:10b<1033::aid-yea983>3.0.co;2-v;
RA Klima R., Coglievina M., Zaccaria P., Bertani I., Bruschi C.V.;
RT "A putative helicase, the SUA5, PMR1, tRNALys1 genes and four open reading
RT frames have been detected in the DNA sequence of an 8.8 kb fragment of the
RT left arm of chromosome VII of Saccharomyces cerevisiae.";
RL Yeast 12:1033-1040(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=12615994; DOI=10.1073/pnas.0530118100;
RA Zewail A., Xie M.W., Xing Y., Lin L., Zhang P.F., Zou W., Saxe J.P.,
RA Huang J.;
RT "Novel functions of the phosphatidylinositol metabolic pathway discovered
RT by a chemical genomics screen with wortmannin.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:3345-3350(2003).
RN [5]
RP CORRECTION TO DISRUPTION PHENOTYPE.
RX PubMed=18069899; DOI=10.1371/journal.pgen.0030222;
RA Jordan P.W., Klein F., Leach D.R.;
RT "Novel roles for selected genes in meiotic DNA processing.";
RL PLoS Genet. 3:E222-E222(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: No increased sensitivity to hydroxyurea.
CC {ECO:0000269|PubMed:12615994}.
CC -!- CAUTION: Deletion HUR1 has been reported to cause increased sensitivity
CC to hydroxyurea (PubMed:12615994). However, HUR1 partially overlaps with
CC PMR1 and a later analysis revealed that deletion of PMR1 but not HUR1
CC affected resistance to hydroxyurea (PubMed:18069899).
CC {ECO:0000305|PubMed:12615994, ECO:0000305|PubMed:18069899}.
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DR EMBL; X85757; CAA59761.1; -; Genomic_DNA.
DR EMBL; Z72690; CAA96879.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07945.1; -; Genomic_DNA.
DR PIR; S59652; S59652.
DR RefSeq; NP_011347.1; NM_001181033.1.
DR AlphaFoldDB; P45820; -.
DR BioGRID; 33086; 570.
DR DIP; DIP-4765N; -.
DR STRING; 4932.YGL168W; -.
DR PaxDb; P45820; -.
DR EnsemblFungi; YGL168W_mRNA; YGL168W; YGL168W.
DR GeneID; 852708; -.
DR KEGG; sce:YGL168W; -.
DR SGD; S000003136; HUR1.
DR VEuPathDB; FungiDB:YGL168W; -.
DR HOGENOM; CLU_2172517_0_0_1; -.
DR BioCyc; YEAST:G3O-30656-MON; -.
DR PRO; PR:P45820; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P45820; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IMP:SGD.
DR GO; GO:0016236; P:macroautophagy; IMP:SGD.
PE 4: Predicted;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..110
FT /note="Putative uncharacterized protein HUR1"
FT /id="PRO_0000202728"
FT TRANSMEM 18..34
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 110 AA; 12515 MW; 304BF9E60B4F09C4 CRC64;
MFILVSVVNI CTYIHLHMFP LISTFTSIGL GVLMKDKGKE GKTIKAQNVT YQTFEKYVES
SSFFFLVHNF LNSSTMKTLL LMSNNNSISE IPSFSVLKIL WKNGIYIAHI
