ID   HUS1B_MOUSE             Reviewed;         276 AA.
AC   Q8K572;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Checkpoint protein HUS1B;
DE            Short=mHUS1B;
GN   Name=Hus1b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=129/SvEv;
RX   PubMed=11944979; DOI=10.1006/geno.2002.6737;
RA   Hang H., Zhang Y., Dunbrack R.L. Jr., Wang C., Lieberman H.B.;
RT   "Identification and characterization of a paralog of human cell cycle
RT   checkpoint gene HUS1.";
RL   Genomics 79:487-492(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBUNIT: Interacts with RAD1 and RAD9B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HUS1 family. {ECO:0000305}.
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DR   EMBL; AF508546; AAM28903.1; -; mRNA.
DR   EMBL; AL606764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS26421.1; -.
DR   RefSeq; NP_694712.1; NM_153072.2.
DR   AlphaFoldDB; Q8K572; -.
DR   SMR; Q8K572; -.
DR   STRING; 10090.ENSMUSP00000100007; -.
DR   PhosphoSitePlus; Q8K572; -.
DR   PaxDb; Q8K572; -.
DR   PRIDE; Q8K572; -.
DR   ProteomicsDB; 273286; -.
DR   Antibodypedia; 24237; 126 antibodies from 28 providers.
DR   DNASU; 210554; -.
DR   Ensembl; ENSMUST00000102943; ENSMUSP00000100007; ENSMUSG00000076430.
DR   GeneID; 210554; -.
DR   KEGG; mmu:210554; -.
DR   UCSC; uc007pzf.2; mouse.
DR   CTD; 135458; -.
DR   MGI; MGI:2671003; Hus1b.
DR   VEuPathDB; HostDB:ENSMUSG00000076430; -.
DR   eggNOG; KOG3999; Eukaryota.
DR   GeneTree; ENSGT00390000000706; -.
DR   HOGENOM; CLU_035754_1_0_1; -.
DR   InParanoid; Q8K572; -.
DR   OMA; IIPASDW; -.
DR   OrthoDB; 1053181at2759; -.
DR   PhylomeDB; Q8K572; -.
DR   TreeFam; TF314491; -.
DR   BioGRID-ORCS; 210554; 0 hits in 106 CRISPR screens.
DR   PRO; PR:Q8K572; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q8K572; protein.
DR   Bgee; ENSMUSG00000076430; Expressed in spermatocyte and 11 other tissues.
DR   ExpressionAtlas; Q8K572; baseline and differential.
DR   GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR   GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0044778; P:meiotic DNA integrity checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR   InterPro; IPR016580; Cell_cycle_HUS1.
DR   InterPro; IPR007150; Hus1/Mec3.
DR   Pfam; PF04005; Hus1; 1.
DR   PIRSF; PIRSF011312; Cell_cycle_HUS1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..276
FT                   /note="Checkpoint protein HUS1B"
FT                   /id="PRO_0000226246"
SQ   SEQUENCE   276 AA;  31251 MW;  4C4A0E326DE4A963 CRC64;
     MRFRARITSK RFIELFIQVS STVAKLAKVC VLRVCPDRLY FCPMGLLGEA QLWGEMRRDV
     FHHFCMEGAS QEFNEICLEL MSEHLARAVK NAGNASSLKL QLTNKQRPCL TLVVELASCP
     GHTRAVVHDL PVRVLPRRRW KDCTEPHVRG SDVSVYLPAL KTLKNMVERM ANVGSHVLVE
     ANLNGRMNLT VETDRVTIKS YFKNLGNPPN AVLCMSQGRD PETMVQVRVD NRKLLQCFDG
     HQINPTMALC NILSNTLLHL VLVHEDISLQ YFIPAS