ID   HUS1_DICDI              Reviewed;         271 AA.
AC   Q54NC0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Checkpoint protein hus1 homolog;
GN   Name=hus1; ORFNames=DDB_G0285353;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Essential in controlling the S-M checkpoint that couples
CC       mitosis to the completion of DNA replication. It is also required for
CC       the response to DNA damage (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HUS1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64751.1; -; Genomic_DNA.
DR   RefSeq; XP_638260.1; XM_633168.1.
DR   AlphaFoldDB; Q54NC0; -.
DR   SMR; Q54NC0; -.
DR   STRING; 44689.DDB0233010; -.
DR   PaxDb; Q54NC0; -.
DR   EnsemblProtists; EAL64751; EAL64751; DDB_G0285353.
DR   GeneID; 8625068; -.
DR   KEGG; ddi:DDB_G0285353; -.
DR   dictyBase; DDB_G0285353; hus1.
DR   eggNOG; KOG3999; Eukaryota.
DR   HOGENOM; CLU_035754_2_0_1; -.
DR   InParanoid; Q54NC0; -.
DR   OMA; PWASEDG; -.
DR   PhylomeDB; Q54NC0; -.
DR   PRO; PR:Q54NC0; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0030896; C:checkpoint clamp complex; ISS:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR   GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; ISS:dictyBase.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; ISS:dictyBase.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0044778; P:meiotic DNA integrity checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR   InterPro; IPR016580; Cell_cycle_HUS1.
DR   InterPro; IPR007150; Hus1/Mec3.
DR   Pfam; PF04005; Hus1; 1.
DR   PIRSF; PIRSF011312; Cell_cycle_HUS1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; DNA damage; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..271
FT                   /note="Checkpoint protein hus1 homolog"
FT                   /id="PRO_0000328201"
SQ   SEQUENCE   271 AA;  30648 MW;  B5CFEB903AE24E67 CRC64;
     MKFKAKISKA SILLKTVQNI MKIYNECICH ITPDKLRFII QSDFNDGMQV FCEIQRSLIF
     ENFTIESLSD NEIQFQLDLE SLRRVLQSAT SNGVSDIFTN LTKVRGGPVL HFIIKSGTSG
     TVIFQDIPIV LLTAQQMAQI NEPTLPDPLV HILLPNLKNL QKVIDKMKNI SDCLKIMIAM
     NNRLSFEVET SSGSISTFYS GLDHPQFGDH VLSPDLQATV CVDIKKFAKV LHIHQLKPSE
     VVLCLYERSI IVHVVLTDIM ITYYLPVLIK N