ID   HUT1_ASHGO              Reviewed;         324 AA.
AC   Q755H7;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UDP-galactose transporter homolog 1;
GN   Name=HUT1; OrderedLocusNames=AFL154C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 89.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: May be involved in specific transport of UDP-Gal from the
CC       cytosol to the Golgi lumen. Involved in the maintenance of optimal
CC       conditions for the folding of secretory pathway proteins in the
CC       endoplasmic reticulum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53220.2; -; Genomic_DNA.
DR   RefSeq; NP_985396.2; NM_210750.2.
DR   AlphaFoldDB; Q755H7; -.
DR   SMR; Q755H7; -.
DR   STRING; 33169.AAS53220; -.
DR   EnsemblFungi; AAS53220; AAS53220; AGOS_AFL154C.
DR   GeneID; 4621622; -.
DR   KEGG; ago:AGOS_AFL154C; -.
DR   eggNOG; KOG1581; Eukaryota.
DR   HOGENOM; CLU_036019_0_2_1; -.
DR   InParanoid; Q755H7; -.
DR   OMA; CGAIGQV; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0072334; P:UDP-galactose transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..324
FT                   /note="UDP-galactose transporter homolog 1"
FT                   /id="PRO_0000213403"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   324 AA;  35343 MW;  D2738CE9EDFEA0CA CRC64;
     MGSQVRLVIA VCGIYATFLT WSLAQEPLTT SVWPNSAARF SHSSFIVLCQ ALTAAVVGLC
     YLKAQRSGYG AREFIRKHWA DVAGISLTQA LSAPAANHSL QYVDYVGYML AKSCKLLPIM
     LVHVLVYRTP IGRDKALVGV LVSGGVALFT LGGAERKQGE ASLYGLGMLL VSLFLDGLTN
     ASQDRLLRRP ASKKITGAHL MVALNTAIVL WNLAYLVLFD RTQWQGSLQQ LHADPAILTY
     LFTYCACGAL GQCFVFFTLE HYSSLVLATV TVTRKMVSML LSIVVYGHSV RPVQWLGILV
     VFGGIIWETV KKGQRGSGQK SKQH