ID   HUT1_CANAL              Reviewed;         370 AA.
AC   Q5ADN8; A0A1D8PKM2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=UDP-galactose transporter homolog 1;
GN   Name=HUT1; OrderedLocusNames=CAALFM_C306980WA;
GN   ORFNames=CaO19.14095, CaO19.6803;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: May be involved in specific transport of UDP-Gal from the
CC       cytosol to the Golgi lumen. Involved in the maintenance of optimal
CC       conditions for the folding of secretory pathway proteins in the
CC       endoplasmic reticulum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CP017625; AOW28701.1; -; Genomic_DNA.
DR   RefSeq; XP_719898.1; XM_714805.1.
DR   AlphaFoldDB; Q5ADN8; -.
DR   SMR; Q5ADN8; -.
DR   STRING; 237561.Q5ADN8; -.
DR   GeneID; 3638505; -.
DR   KEGG; cal:CAALFM_C306980WA; -.
DR   CGD; CAL0000194078; HUT1.
DR   VEuPathDB; FungiDB:C3_06980W_A; -.
DR   eggNOG; KOG1581; Eukaryota.
DR   HOGENOM; CLU_036019_0_2_1; -.
DR   InParanoid; Q5ADN8; -.
DR   OMA; CGAIGQV; -.
DR   OrthoDB; 1220063at2759; -.
DR   PRO; PR:Q5ADN8; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0072334; P:UDP-galactose transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..370
FT                   /note="UDP-galactose transporter homolog 1"
FT                   /id="PRO_0000213405"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   370 AA;  41894 MW;  53EE3BAA1322891E CRC64;
     MTTQKQHQQQ HHLQSGQEKN KALTLIICVC GLYGTFLTWS ILQERINTKP YGDNNEYFKA
     PIIINLIQAL FASIIGFIYN YVTTTTTSTK TTTKTKTKTN SNPFSIFFTN GKQNCNVLKF
     MILISITSSI ASPIGYKSLK HLDYLAYLLA KSCKLIPVMI VHFIFYQTKF PNYKYLVAGL
     VTLGVILFTM AHVTTKTKIN DGNTLLGLTY LIGSMILDGL TNSTQDQLFK LPLENKLTSG
     KLMSLLNLFI FIWTSLYTII FHKYEIDYTI NFINNYPELL IDIIGFAICG AIGQVFIFII
     LEKFDSIILI TATVTRKMLS MILSVILFGH HLSWEQWVGV GLVFGGIGLE AFIKFKQQSQ
     QKMKIKSKVA