ID   HUT1_CANGA              Reviewed;         362 AA.
AC   Q6FSF8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=UDP-galactose transporter homolog 1;
GN   Name=HUT1; OrderedLocusNames=CAGL0H00847g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in specific transport of UDP-Gal from the
CC       cytosol to the Golgi lumen. Involved in the maintenance of optimal
CC       conditions for the folding of secretory pathway proteins in the
CC       endoplasmic reticulum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CR380954; CAG59767.1; -; Genomic_DNA.
DR   RefSeq; XP_446836.1; XM_446836.1.
DR   AlphaFoldDB; Q6FSF8; -.
DR   SMR; Q6FSF8; -.
DR   STRING; 5478.XP_446836.1; -.
DR   EnsemblFungi; CAG59767; CAG59767; CAGL0H00847g.
DR   GeneID; 2888648; -.
DR   KEGG; cgr:CAGL0H00847g; -.
DR   CGD; CAL0130036; CAGL0H00847g.
DR   VEuPathDB; FungiDB:CAGL0H00847g; -.
DR   eggNOG; KOG1581; Eukaryota.
DR   HOGENOM; CLU_036019_0_2_1; -.
DR   InParanoid; Q6FSF8; -.
DR   OMA; CGAIGQV; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0072334; P:UDP-galactose transmembrane transport; IEA:EnsemblFungi.
DR   GO; GO:0015786; P:UDP-glucose transmembrane transport; IEA:EnsemblFungi.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 2.
DR   Pfam; PF08449; UAA; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..362
FT                   /note="UDP-galactose transporter homolog 1"
FT                   /id="PRO_0000213406"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        196
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   362 AA;  40395 MW;  D7A9FEE2D5FCBBA3 CRC64;
     MSKSNSIFPV LFCAAGIYAS FLTWALVQEP LTTQVWENSH KRFQCPNVIA VVQAVAAVCV
     GYFYMRAKGA QRNYGAIAMV RDYAKPLALI SFTQSASSPL SQYALQYVDY LTYMLAKSCK
     MIPVLLVHLI IYRTTISRKK SVVAVLVSIG VTIFTIGGSK GKISGSISGS NDEHFFQKAS
     GFLLLFLSLF MDGLTNATQD KMLKNNRVQM AIQNAETQDK KQQHKVFHTL TGAHMMFALN
     FFVAIWNIAY LLVIDRGQIC NAHAMLKKDP IIVSYLLAYA LCGSLGQCFI FYTLELYGSL
     VLIMITVTRK MMSMLLSIIV FGKTVNATQW LGIVIVFSGI TWEALDKRRE KKALEAKVQK
     SE