HUT1_CRYNJ
ID HUT1_CRYNJ Reviewed; 412 AA.
AC P0CP32; Q55LQ9; Q5K915;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=UDP-galactose transporter homolog 1;
GN Name=HUT1-A; OrderedLocusNames=CNL03760;
GN and
GN Name=HUT1-B; OrderedLocusNames=CNH03760;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: May be involved in specific transport of UDP-Gal from the
CC cytosol to the Golgi lumen. Involved in the maintenance of optimal
CC conditions for the folding of secretory pathway proteins in the
CC endoplasmic reticulum (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: There are two genes coding for HUT1 in strain JEC21, due
CC to a translocation and segmental duplication on chromosomes 8 and 12.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017352; AAW46420.1; -; Genomic_DNA.
DR EMBL; AE017348; AAW45229.1; -; Genomic_DNA.
DR RefSeq; XP_567937.1; XM_567937.1.
DR RefSeq; XP_572536.1; XM_572536.1.
DR AlphaFoldDB; P0CP32; -.
DR STRING; 5207.AAW45229; -.
DR PaxDb; P0CP32; -.
DR EnsemblFungi; AAW45229; AAW45229; CNH03760.
DR EnsemblFungi; AAW46420; AAW46420; CNL03760.
DR GeneID; 3255035; -.
DR GeneID; 3259191; -.
DR KEGG; cne:CNH03760; -.
DR KEGG; cne:CNL03760; -.
DR VEuPathDB; FungiDB:CNH03760; -.
DR VEuPathDB; FungiDB:CNL03760; -.
DR eggNOG; KOG1581; Eukaryota.
DR HOGENOM; CLU_036019_0_0_1; -.
DR InParanoid; P0CP32; -.
DR OMA; YLQCSAF; -.
DR OrthoDB; 1220063at2759; -.
DR Proteomes; UP000002149; Chromosome 12.
DR Proteomes; UP000002149; Chromosome 8.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..412
FT /note="UDP-galactose transporter homolog 1"
FT /id="PRO_0000213407"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 31..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 244
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 412 AA; 44919 MW; 7B7004D028DB19ED CRC64;
MGVLRLAVCI SGVYAAFLLW AIAQERLSKP FPSVHPHPHQ QPHSPSDPPP GDKFPSPLFL
NFAQALASSL SALCYLSFKA WRDGWKGRGL GQLLGLKEVF GKSQTALNGD AKANKKESEL
NEKTKEVVEK APKPPKKSLL ALLVQVSVFQ TIASPIGFLA LRHISYPTMV LGKSCKLIPV
LLLNVLLYRR KFSPHKYIVV ALVTVGISMF MLFAETSKKK KGGSDSMWGL VLLLVNLLID
GLTNSTQDQI FSSYPSYTGQ QMMFTMALTT QIILLPLLVL PLPTNPISLL AHLPPPFGSS
VPTSTLSFSP PAALESISFL LSHPSALAPL FAYALLGGLG QLFIFETIQH FGSLTLVMVT
VTRKLFTMLL SVVVFEHRLT KGQWLGVGVV FAGIGVEAGM KRKDVMKKAK KD
