ID   HUT1_DEBHA              Reviewed;         354 AA.
AC   Q6BMV3; B5RU80;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=UDP-galactose transporter homolog 1;
GN   Name=HUT1; OrderedLocusNames=DEHA2F02376g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in specific transport of UDP-Gal from the
CC       cytosol to the Golgi lumen. Involved in the maintenance of optimal
CC       conditions for the folding of secretory pathway proteins in the
CC       endoplasmic reticulum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CR382138; CAR66257.1; -; Genomic_DNA.
DR   RefSeq; XP_002770726.1; XM_002770680.1.
DR   AlphaFoldDB; Q6BMV3; -.
DR   STRING; 4959.XP_002770726.1; -.
DR   EnsemblFungi; CAR66257; CAR66257; DEHA2F02376g.
DR   GeneID; 8998860; -.
DR   KEGG; dha:DEHA2F02376g; -.
DR   VEuPathDB; FungiDB:DEHA2F02376g; -.
DR   eggNOG; KOG1581; Eukaryota.
DR   HOGENOM; CLU_036019_0_2_1; -.
DR   InParanoid; Q6BMV3; -.
DR   OMA; CGAIGQV; -.
DR   OrthoDB; 1220063at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..354
FT                   /note="UDP-galactose transporter homolog 1"
FT                   /id="PRO_0000213408"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        202
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   354 AA;  38849 MW;  35328AE734A30D46 CRC64;
     MKKEGGGSII TLAACILGLY ASFLTWSVLQ ERISTKPYGS NPDTGSPDFF KAPLVINIIQ
     AFFASIVGLI YSVVSSRSNP LSIFTQNEKP VALKFFKSFV IISLTSSLSS PLGYESLKHV
     DYLAYLLAKS CKLIPVMLVH FVLYRTKFPL YKCMVAGSVT VGVIIFTLSH SSTKSKADIS
     DGKTALGMAQ LIGSMLLDGL TNSTQDQLFK LRGTSPSNKH TKLTGAYLMC ILNAFIFINT
     LAYALIFKYQ SEITYTVNFV HHYPQVMMNI LEFAILGSVG QVFVFIILEK FDSLILITST
     VTRKMISMIL SVVLFGHQLN GLQWGGVGLV FGGIGYEALV KMSMNKAPTT KKNQ