HUT1_SCHPO
ID HUT1_SCHPO Reviewed; 322 AA.
AC Q8WZJ9;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=UDP-galactose transporter homolog 1;
GN Name=hut1; ORFNames=SPBC839.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=11284010; DOI=10.1002/yea.707.abs;
RA Nakanishi H., Nakayama K., Yokota A., Tachikawa H., Takahashi N.,
RA Jigami Y.;
RT "Hut1 proteins identified in Saccharomyces cerevisiae and
RT Schizosaccharomyces pombe are functional homologues involved in the
RT protein-folding process at the endoplasmic reticulum.";
RL Yeast 18:543-554(2001).
CC -!- FUNCTION: May be involved in specific transport of UDP-Gal from the
CC cytosol to the Golgi lumen (By similarity). Involved in the maintenance
CC of optimal conditions for the folding of secretory pathway proteins in
CC the endoplasmic reticulum. {ECO:0000250, ECO:0000269|PubMed:11284010}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
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DR EMBL; CU329671; CAB46704.1; -; Genomic_DNA.
DR PIR; T40718; T40718.
DR RefSeq; NP_595251.1; NM_001021157.2.
DR AlphaFoldDB; Q8WZJ9; -.
DR SMR; Q8WZJ9; -.
DR BioGRID; 277720; 6.
DR STRING; 4896.SPBC839.11c.1; -.
DR MaxQB; Q8WZJ9; -.
DR PaxDb; Q8WZJ9; -.
DR EnsemblFungi; SPBC839.11c.1; SPBC839.11c.1:pep; SPBC839.11c.
DR GeneID; 2541206; -.
DR KEGG; spo:SPBC839.11c; -.
DR PomBase; SPBC839.11c; hut1.
DR VEuPathDB; FungiDB:SPBC839.11c; -.
DR eggNOG; KOG1581; Eukaryota.
DR HOGENOM; CLU_036019_0_0_1; -.
DR InParanoid; Q8WZJ9; -.
DR OMA; VCSNMAL; -.
DR PhylomeDB; Q8WZJ9; -.
DR PRO; PR:Q8WZJ9; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; EXP:PomBase.
DR GO; GO:0000139; C:Golgi membrane; EXP:PomBase.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IGI:PomBase.
DR GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; EXP:PomBase.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IGI:PomBase.
DR GO; GO:0015786; P:UDP-glucose transmembrane transport; IDA:PomBase.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..322
FT /note="UDP-galactose transporter homolog 1"
FT /id="PRO_0000213411"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 35933 MW; 98E9607A73935D2C CRC64;
MAGFMRQLFV CMIGIYGSFL SWAVMQEKII TRPYDGERFS SPALLSLAQS FMTVLCGLLW
NWFHGVSARG LLEPKFLGYF SSIAISASLS SYFGYASMFH LSYPTVILGK SCKLLPVIAL
HVFVYKRKFP PHKYLIVTMI TAGVSIFSYF QNTSSKGKHA EHDSPIGLLL LFFNLLMDGI
TNTTQDKVFG KYKLSSVTMM IAVNLGIACL NGLYLISPFC NQQPLSFINR HPSILKDMLL
FACTGSVGQL FIFFTLEKFG SITLVTITLT RKIFTMLLSV FHFHHTVSSI QWLGILLVFL
GISLEAGLKI LNNNSTAKKK AS
