ID   HUT1_YARLI              Reviewed;         365 AA.
AC   Q6C4X5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=UDP-galactose transporter homolog 1;
GN   Name=HUT1; OrderedLocusNames=YALI0E22957g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May be involved in specific transport of UDP-Gal from the
CC       cytosol to the Golgi lumen. Involved in the maintenance of optimal
CC       conditions for the folding of secretory pathway proteins in the
CC       endoplasmic reticulum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79886.1; -; Genomic_DNA.
DR   RefSeq; XP_504287.1; XM_504287.1.
DR   AlphaFoldDB; Q6C4X5; -.
DR   SMR; Q6C4X5; -.
DR   STRING; 4952.CAG79886; -.
DR   EnsemblFungi; CAG79886; CAG79886; YALI0_E22957g.
DR   GeneID; 2912920; -.
DR   KEGG; yli:YALI0E22957g; -.
DR   VEuPathDB; FungiDB:YALI0_E22957g; -.
DR   HOGENOM; CLU_036019_0_2_1; -.
DR   InParanoid; Q6C4X5; -.
DR   OMA; CGAIGQV; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0072334; P:UDP-galactose transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..365
FT                   /note="UDP-galactose transporter homolog 1"
FT                   /id="PRO_0000213413"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   365 AA;  40292 MW;  2DF10A95F4B5AC4F CRC64;
     MSELRKRNQA AIADLSENIE VTETVELTEK KPETTKSTKG HIIDLIICVS GIYASFLTWA
     VLQERIATTP YGPDNKIFRA SLVINTVQSF LAAAVGYAYL QYKQSRRAAK GLKKNTTVFD
     SMYTLKQLSL VALSQSLASP LSYTALKYVD YLTSILAKSC KLIPLMALQV TLYRRKFPAY
     KYAVVVLVTI GVSMFTIFHA APKKASGAGS EHQLYGLGLL GISMLLDGLT NSTQDQIFRK
     NADITGPHVM CGLNLLTGVF TTVSLLTFSR PQLDTAIAFI RLHPEIMRDI VLFGLCGAVG
     QVFIFQTLEK FGSVVLVTVN VTRKMFSMLL SVVWFNHRLT LGQWAGVAAV FGGIGFEAWM
     KMKKN