ID   HUTC_KLEAE              Reviewed;         241 AA.
AC   P12380;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Histidine utilization repressor;
GN   Name=hutC;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2203754; DOI=10.1128/jb.172.9.5477-5481.1990;
RA   Schwacha A., Bender R.A.;
RT   "Nucleotide sequence of the gene encoding the repressor for the histidine
RT   utilization genes of Klebsiella aerogenes.";
RL   J. Bacteriol. 172:5477-5481(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-241.
RX   PubMed=2834335; DOI=10.1128/jb.170.5.2240-2246.1988;
RA   Nieuwkoop A.J., Baldauf S.A., Hudspeth M.E.S., Bender R.A.;
RT   "Bidirectional promoter in the hut(P) region of the histidine utilization
RT   (hut) operons from Klebsiella aerogenes.";
RL   J. Bacteriol. 170:2240-2246(1988).
CC   -!- FUNCTION: Repressor which binds to the hutP region in the histidine
CC       utilization (hut) operon. It blocks the expression of all the hut genes
CC       in the absence of inducer.
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate [regulation].
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DR   EMBL; M34604; AAA25075.1; -; Genomic_DNA.
DR   EMBL; M19665; AAA25077.1; -; Genomic_DNA.
DR   RefSeq; WP_002895358.1; NZ_LR134254.1.
DR   AlphaFoldDB; P12380; -.
DR   SMR; P12380; -.
DR   STRING; 548.EAG7_02610; -.
DR   PRIDE; P12380; -.
DR   UniPathway; UPA00379; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR010248; His_ut_repres.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   TIGRFAMs; TIGR02018; his_ut_repres; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Histidine metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Histidine utilization repressor"
FT                   /id="PRO_0000050649"
FT   DOMAIN          11..79
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        39..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   241 AA;  27215 MW;  61D1AB625BEAFB3B CRC64;
     MFAQQPRSAP APFYEKVKQA ISEKIHSGVW RPHDRIPSEA ELVAQFGFSR MTINRALREL
     TDEGLLVRLQ GVGTFVAEPK GQSALFEVRS IAAEIVARHH QHRCEVLLLE ETRADHIQAT
     ALSVPEGTRI FHSLMVHYEN EVPVQIEDRC VNAAVVPDYL HQDYTATTPH DYLSLIAPLT
     EGEHIVEAVQ ATAEECALLH IHAHDPCLLI RRRTWSTTHI VSHARLLFPG SRYRLQGRFG
     S