ID   HUTC_PSEAE              Reviewed;         250 AA.
AC   Q9HU78;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Histidine utilization repressor;
GN   Name=hutC; OrderedLocusNames=PA5105;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Repressor which binds to the hutP region in the histidine
CC       utilization (hut) operon. It blocks the expression of all the hut genes
CC       in the absence of inducer (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate [regulation].
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004091; AAG08490.1; -; Genomic_DNA.
DR   PIR; B83008; B83008.
DR   RefSeq; NP_253792.1; NC_002516.2.
DR   RefSeq; WP_003095970.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; Q9HU78; -.
DR   SMR; Q9HU78; -.
DR   STRING; 287.DR97_2459; -.
DR   PaxDb; Q9HU78; -.
DR   PRIDE; Q9HU78; -.
DR   DNASU; 883034; -.
DR   EnsemblBacteria; AAG08490; AAG08490; PA5105.
DR   GeneID; 883034; -.
DR   KEGG; pae:PA5105; -.
DR   PATRIC; fig|208964.12.peg.5350; -.
DR   PseudoCAP; PA5105; -.
DR   HOGENOM; CLU_063236_0_0_6; -.
DR   InParanoid; Q9HU78; -.
DR   OMA; LDMREGQ; -.
DR   PhylomeDB; Q9HU78; -.
DR   BioCyc; PAER208964:G1FZ6-5220-MON; -.
DR   UniPathway; UPA00379; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR010248; His_ut_repres.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   TIGRFAMs; TIGR02018; his_ut_repres; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Histidine metabolism; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..250
FT                   /note="Histidine utilization repressor"
FT                   /id="PRO_0000287777"
FT   DOMAIN          20..88
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        48..67
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   250 AA;  27812 MW;  6919F1EADD3184A6 CRC64;
     MTSSSSDRSP LASQLGEVPA PLYARVKQMI VSQIQSGAWP PHHRVPSESE LVSQLGFSRM
     TINRALRELT SDGLLVRMQG VGTFVAEPKG QSALFEVHNI ADEIAARGHR HRCQVITLGE
     EVAGPERALA LDVREGQRVF HSLIVHYEND IPVQIEDRYV NAAVAPDYLK QDFTRQTPYA
     YLTQVAPLTE GEHVVEAILA EPAECKLLQI ERGEPCLLIR RRTWSGRVAV TAARLLHPGS
     RHRLEGRFSS