ID   HUTC_PSEPU              Reviewed;         248 AA.
AC   P22773;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Histidine utilization repressor;
GN   Name=hutC;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2203753; DOI=10.1128/jb.172.9.5470-5476.1990;
RA   Allison S.L., Phillips A.T.;
RT   "Nucleotide sequence of the gene encoding the repressor for the histidine
RT   utilization genes of Pseudomonas putida.";
RL   J. Bacteriol. 172:5470-5476(1990).
CC   -!- FUNCTION: Repressor which binds to the hutP region in the histidine
CC       utilization (hut) operon. It blocks the expression of all the hut genes
CC       in the absence of inducer.
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate [regulation].
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DR   EMBL; M33922; AAA25841.1; -; Genomic_DNA.
DR   PIR; A36729; A36729.
DR   RefSeq; WP_016502008.1; NZ_WOWR01000002.1.
DR   AlphaFoldDB; P22773; -.
DR   SMR; P22773; -.
DR   STRING; 1240350.AMZE01000043_gene152; -.
DR   GeneID; 45526579; -.
DR   eggNOG; COG2188; Bacteria.
DR   UniPathway; UPA00379; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR010248; His_ut_repres.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   TIGRFAMs; TIGR02018; his_ut_repres; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Histidine metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..248
FT                   /note="Histidine utilization repressor"
FT                   /id="PRO_0000050650"
FT   DOMAIN          18..86
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        46..65
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   248 AA;  27682 MW;  EA149B07A73F2FE8 CRC64;
     MPTPPVSALV AQMGEGPAPL YARVKQMIIQ QIDNGSWPPH HRVPSESELV NELGFSRMTI
     NRALRELTAD GLLVRMQGVG TFVAEPKGRS ALFEVNNIAD EIAARGHQHS CQVITLTEEA
     AGSERALALD MREGQRVFHS LIVHFENGVP VQIEDRYVNA AIAPDYLKQD FTRQTPYAYL
     SQVAPLTEGE HVVEAILAEP EECRLLQIER GEPCLLIRRR TWSGRQPVTA ARLIHPGSRH
     RLEGRFSK