ID   3X_MICLE                Reviewed;          12 AA.
AC   P0DJB0;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   02-DEC-2020, entry version 15.
DE   RecName: Full=Muscarinic toxin Mlalpha;
DE            Short=MT-Mlalpha;
DE   Flags: Fragment;
OS   Micrurus lemniscatus (South American coral snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=129464;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=22005021; DOI=10.1016/j.lfs.2011.09.024;
RA   da Silva D.C., de Medeiros W.A., Batista I.D., Pimenta D.C., Lebrun I.,
RA   Abdalla F.M., Sandoval M.R.;
RT   "Characterization of a new muscarinic toxin from the venom of the Brazilian
RT   coral snake Micrurus lemniscatus in rat hippocampus.";
RL   Life Sci. 89:931-938(2011).
CC   -!- FUNCTION: Probably blocks muscarinic acetylcholine receptors (CHRM),
CC       since it inhibits the binding of the selective muscarinic ligand
CC       [3H]QNB and inhibits the carbachol-induced [3H]inositol phosphate
CC       accumulation in rat hippocampus. {ECO:0000269|PubMed:22005021}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22005021}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=7048.12; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:22005021};
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond;
KW   G-protein coupled acetylcholine receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..>12
FT                   /note="Muscarinic toxin Mlalpha"
FT                   /id="PRO_0000414301"
FT   NON_TER         12
SQ   SEQUENCE   12 AA;  1352 MW;  1A6114C409B9CEB0 CRC64;
     LICFICFSPT AH