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HUTM_BACSU
ID   HUTM_BACSU              Reviewed;         475 AA.
AC   P42087;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative histidine permease;
GN   Name=hutM; OrderedLocusNames=BSU39390; ORFNames=EE57D;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=7704263; DOI=10.1099/13500872-141-2-337;
RA   Yoshida K., Sano H., Seki S., Oda M., Fujimura M., Fujita Y.;
RT   "Cloning and sequencing of a 29 kb region of the Bacillus subtilis genome
RT   containing the hut and wapA loci.";
RL   Microbiology 141:337-343(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 74-75.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 360-475.
RC   STRAIN=168;
RX   PubMed=8550462; DOI=10.1128/jb.178.2.424-434.1996;
RA   Saxild H.H., Andersen L.N., Hammer K.;
RT   "Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction
RT   by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded
RT   DeoR repressor protein.";
RL   J. Bacteriol. 178:424-434(1996).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 361-475.
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=8867804; DOI=10.1093/dnares/2.6.295;
RA   Yoshida K., Fujimyra M., Yanai N., Fujita Y.;
RT   "Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome
RT   between the iol and hut operons.";
RL   DNA Res. 2:295-301(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. {ECO:0000305}.
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DR   EMBL; D31856; BAA06640.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15975.2; -; Genomic_DNA.
DR   EMBL; X82174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; D45912; BAA08340.1; -; Genomic_DNA.
DR   PIR; E69643; E69643.
DR   RefSeq; NP_391818.2; NC_000964.3.
DR   RefSeq; WP_003227134.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P42087; -.
DR   SMR; P42087; -.
DR   STRING; 224308.BSU39390; -.
DR   PaxDb; P42087; -.
DR   PRIDE; P42087; -.
DR   EnsemblBacteria; CAB15975; CAB15975; BSU_39390.
DR   GeneID; 938565; -.
DR   KEGG; bsu:BSU39390; -.
DR   PATRIC; fig|224308.179.peg.4264; -.
DR   eggNOG; COG0833; Bacteria.
DR   InParanoid; P42087; -.
DR   OMA; RTVIFFI; -.
DR   PhylomeDB; P42087; -.
DR   BioCyc; BSUB:BSU39390-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..475
FT                   /note="Putative histidine permease"
FT                   /id="PRO_0000054203"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        74..75
FT                   /note="MP -> NA (in Ref. 1; BAA06640)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   475 AA;  51624 MW;  CD686DE3B71CA7FF CRC64;
     MNLQENSSQQ LKRTMKSRHL FMISLGGVIG TGLFLSTGYT LHQAGPGGTI LAYVIGGLMM
     YLVMQCLGEL SVAMPVTGSF QKYATTFIGP STGFMVGIMY WINWVVTVGS EFTASGILMQ
     RWFPDSSVWM WSAIFAALLF ICNAFSVKLF AETEFWFSSV KIVTIILFII LGGAAMFGLI
     SLNGTADAPM LSNFTDHGGL FPNGFLAVFI AMISVSFAFS GTELIGVTAG ESANPQKDIP
     RSIRNVAWRT VIFFIGAVFI LSGLISWKDA GVIESPFVAV FAEIGIPYAA DIMNFVILTA
     LLSVANSGLY ASTRMMWSLA NENMISSRFK KVTSKGIPLN ALMISMAVSC LSLVSSIVAP
     GTVYVVMVAI AGFAGVVVWM SIALSQLLFR KRFLKKGGDV KDLTFRTPLY PLMPIAALLL
     CSASCIGLAF DPNQRIALFC GVPCIILCYL IYHFKRNVTK AKKISQEEYP ADHIL
 
 
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