ID   HUTP_ALKHC              Reviewed;         147 AA.
AC   Q9KBE7;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Hut operon positive regulatory protein;
GN   Name=hutP; OrderedLocusNames=BH1981;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Antiterminator that binds to cis-acting regulatory sequences
CC       on the mRNA in the presence of histidine, thereby suppressing
CC       transcription termination and activating the hut operon for histidine
CC       utilization. {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HutP family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB05700.1; -; Genomic_DNA.
DR   PIR; E83897; E83897.
DR   RefSeq; WP_010898139.1; NC_002570.2.
DR   AlphaFoldDB; Q9KBE7; -.
DR   SMR; Q9KBE7; -.
DR   STRING; 272558.10174599; -.
DR   EnsemblBacteria; BAB05700; BAB05700; BAB05700.
DR   KEGG; bha:BH1981; -.
DR   eggNOG; ENOG502ZFIH; Bacteria.
DR   HOGENOM; CLU_148478_0_0_9; -.
DR   OMA; REMHALY; -.
DR   OrthoDB; 1589374at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006547; P:histidine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1510.10; -; 1.
DR   HAMAP; MF_00779; HutP; 1.
DR   InterPro; IPR015111; Regulatory_HutP.
DR   InterPro; IPR023552; Regulatory_HutP_bacillales.
DR   InterPro; IPR036482; Regulatory_HutP_sf.
DR   Pfam; PF09021; HutP; 1.
DR   SUPFAM; SSF111064; SSF111064; 1.
PE   3: Inferred from homology;
KW   Activator; Histidine metabolism; Reference proteome; RNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..147
FT                   /note="Hut operon positive regulatory protein"
FT                   /id="PRO_0000203790"
SQ   SEQUENCE   147 AA;  15917 MW;  9F6CB20A9F8F0679 CRC64;
     MSKHKSHRIG QLAILLAVSE EPGIVEASIL SSDYQSCIGR VGSMESNKIV AAIETAAKKN
     GFIREGVYRE AHALYHAIIE ALHGVTRGQV QLGSFQRTVG LRFAIVRGKP YKEEAEGEWI
     AVALYGTIGA PIKGQEHETI GLGINHI