HUTP_BACCN
ID HUTP_BACCN Reviewed; 146 AA.
AC A7GR01;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Hut operon positive regulatory protein {ECO:0000255|HAMAP-Rule:MF_00779};
GN Name=hutP {ECO:0000255|HAMAP-Rule:MF_00779}; OrderedLocusNames=Bcer98_2313;
OS Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=315749;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22905 / CIP 110041 / 391-98 / NVH 391-98;
RX PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "Extending the Bacillus cereus group genomics to putative food-borne
RT pathogens of different toxicity.";
RL Chem. Biol. Interact. 171:236-249(2008).
CC -!- FUNCTION: Antiterminator that binds to cis-acting regulatory sequences
CC on the mRNA in the presence of histidine, thereby suppressing
CC transcription termination and activating the hut operon for histidine
CC utilization. {ECO:0000255|HAMAP-Rule:MF_00779}.
CC -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00779}.
CC -!- SIMILARITY: Belongs to the HutP family. {ECO:0000255|HAMAP-
CC Rule:MF_00779}.
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DR EMBL; CP000764; ABS22559.1; -; Genomic_DNA.
DR RefSeq; WP_012094755.1; NC_009674.1.
DR AlphaFoldDB; A7GR01; -.
DR SMR; A7GR01; -.
DR STRING; 315749.Bcer98_2313; -.
DR EnsemblBacteria; ABS22559; ABS22559; Bcer98_2313.
DR GeneID; 56417862; -.
DR KEGG; bcy:Bcer98_2313; -.
DR eggNOG; ENOG502ZFIH; Bacteria.
DR HOGENOM; CLU_148478_0_0_9; -.
DR OMA; REMHALY; -.
DR OrthoDB; 1589374at2; -.
DR Proteomes; UP000002300; Chromosome.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006547; P:histidine metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1510.10; -; 1.
DR HAMAP; MF_00779; HutP; 1.
DR InterPro; IPR015111; Regulatory_HutP.
DR InterPro; IPR023552; Regulatory_HutP_bacillales.
DR InterPro; IPR036482; Regulatory_HutP_sf.
DR Pfam; PF09021; HutP; 1.
DR SUPFAM; SSF111064; SSF111064; 1.
PE 3: Inferred from homology;
KW Activator; Histidine metabolism; RNA-binding; Transcription;
KW Transcription regulation.
FT CHAIN 1..146
FT /note="Hut operon positive regulatory protein"
FT /id="PRO_1000148462"
SQ SEQUENCE 146 AA; 15785 MW; EB16A5976F47771E CRC64;
MLLQGTHRIG RMAMLLALAD ESESSVLSIP KGWKYCTGKV GSMNSQKVVA AMETAAKSNQ
VIETDVYRET HALYHAIMEA LYGVTRGQIQ LADVLRTVGL RFAIVRGTPY DGKKEGEWVA
VALYGTIGAP VKGSEHEAIG LGINHI