ID   HUTP_BACCZ              Reviewed;         146 AA.
AC   Q637H7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Hut operon positive regulatory protein {ECO:0000255|HAMAP-Rule:MF_00779};
GN   Name=hutP {ECO:0000255|HAMAP-Rule:MF_00779}; OrderedLocusNames=BCE33L3355;
OS   Bacillus cereus (strain ZK / E33L).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=288681;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZK / E33L;
RX   PubMed=16621833; DOI=10.1128/jb.188.9.3382-3390.2006;
RA   Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D.,
RA   Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA   Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA   Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R.,
RA   Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M.,
RA   Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B.,
RA   Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R.,
RA   Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA   Brettin T.S., Gilna P.;
RT   "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT   thuringiensis isolates closely related to Bacillus anthracis.";
RL   J. Bacteriol. 188:3382-3390(2006).
CC   -!- FUNCTION: Antiterminator that binds to cis-acting regulatory sequences
CC       on the mRNA in the presence of histidine, thereby suppressing
CC       transcription termination and activating the hut operon for histidine
CC       utilization. {ECO:0000255|HAMAP-Rule:MF_00779}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00779}.
CC   -!- SIMILARITY: Belongs to the HutP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00779}.
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DR   EMBL; CP000001; AAU16914.1; -; Genomic_DNA.
DR   RefSeq; WP_000926513.1; NZ_CP009968.1.
DR   AlphaFoldDB; Q637H7; -.
DR   SMR; Q637H7; -.
DR   EnsemblBacteria; AAU16914; AAU16914; BCE33L3355.
DR   KEGG; bcz:BCE33L3355; -.
DR   PATRIC; fig|288681.22.peg.2068; -.
DR   OMA; REMHALY; -.
DR   Proteomes; UP000002612; Chromosome.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006547; P:histidine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1510.10; -; 1.
DR   HAMAP; MF_00779; HutP; 1.
DR   InterPro; IPR015111; Regulatory_HutP.
DR   InterPro; IPR023552; Regulatory_HutP_bacillales.
DR   InterPro; IPR036482; Regulatory_HutP_sf.
DR   Pfam; PF09021; HutP; 1.
DR   SUPFAM; SSF111064; SSF111064; 1.
PE   3: Inferred from homology;
KW   Activator; Histidine metabolism; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..146
FT                   /note="Hut operon positive regulatory protein"
FT                   /id="PRO_1000148464"
SQ   SEQUENCE   146 AA;  15880 MW;  4817652D456C07AB CRC64;
     MLLQGTHRIG RMAMLLALAD ENESPVLSIP KDWKYCTGKV GSMNSQKVVA AMETAAKSNQ
     VIETDVYRET HALYHAIMEA LYGVTRGQIQ LADVLRTVGL RFAIVRGTPY DGKKEGEWVA
     VALYGTIGAP VKGSEHEAIG LGINHI