ID   HUTP_GEOSW              Reviewed;         149 AA.
AC   C5D4K0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Hut operon positive regulatory protein {ECO:0000255|HAMAP-Rule:MF_00779};
GN   Name=hutP {ECO:0000255|HAMAP-Rule:MF_00779}; OrderedLocusNames=GWCH70_0280;
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=471223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antiterminator that binds to cis-acting regulatory sequences
CC       on the mRNA in the presence of histidine, thereby suppressing
CC       transcription termination and activating the hut operon for histidine
CC       utilization. {ECO:0000255|HAMAP-Rule:MF_00779}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00779}.
CC   -!- SIMILARITY: Belongs to the HutP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00779}.
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DR   EMBL; CP001638; ACS23208.1; -; Genomic_DNA.
DR   RefSeq; WP_012749025.1; NC_012793.1.
DR   AlphaFoldDB; C5D4K0; -.
DR   SMR; C5D4K0; -.
DR   STRING; 471223.GWCH70_0280; -.
DR   EnsemblBacteria; ACS23208; ACS23208; GWCH70_0280.
DR   KEGG; gwc:GWCH70_0280; -.
DR   eggNOG; ENOG502ZFIH; Bacteria.
DR   HOGENOM; CLU_148478_0_0_9; -.
DR   OMA; REMHALY; -.
DR   OrthoDB; 1589374at2; -.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006547; P:histidine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1510.10; -; 1.
DR   HAMAP; MF_00779; HutP; 1.
DR   InterPro; IPR015111; Regulatory_HutP.
DR   InterPro; IPR023552; Regulatory_HutP_bacillales.
DR   InterPro; IPR036482; Regulatory_HutP_sf.
DR   Pfam; PF09021; HutP; 1.
DR   SUPFAM; SSF111064; SSF111064; 1.
PE   3: Inferred from homology;
KW   Activator; Histidine metabolism; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..149
FT                   /note="Hut operon positive regulatory protein"
FT                   /id="PRO_1000212920"
SQ   SEQUENCE   149 AA;  16481 MW;  58D119E6D7E3820C CRC64;
     MLKQAKGRIG RNAVLLALFE EEEEGKITAH LDNLQWRYCK GKVGSMELQK IVASVETAAK
     RNNVVNGELY REMHALYHAV VEAVQGVTRG QVELGDLMRT VGLRFAVVRG NPYENSKEGE
     WIAVALYGTI GAPIRGLEHE TIGLGINHI