ID   HUTU_KLEAE              Reviewed;           9 AA.
AC   P12381;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Urocanate hydratase;
DE            Short=Urocanase;
DE            EC=4.2.1.49;
DE   AltName: Full=Imidazolonepropionate hydrolase;
DE   Flags: Fragment;
GN   Name=hutU;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2834335; DOI=10.1128/jb.170.5.2240-2246.1988;
RA   Nieuwkoop A.J., Baldauf S.A., Hudspeth M.E.S., Bender R.A.;
RT   "Bidirectional promoter in the hut(P) region of the histidine utilization
RT   (hut) operons from Klebsiella aerogenes.";
RL   J. Bacteriol. 170:2240-2246(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2203754; DOI=10.1128/jb.172.9.5477-5481.1990;
RA   Schwacha A., Bender R.A.;
RT   "Nucleotide sequence of the gene encoding the repressor for the histidine
RT   utilization genes of Klebsiella aerogenes.";
RL   J. Bacteriol. 172:5477-5481(1990).
CC   -!- FUNCTION: Catalyzes the conversion of urocanate to 4-imidazolone-5-
CC       propionate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-imidazolone-5-propanoate = H2O + trans-urocanate;
CC         Xref=Rhea:RHEA:13101, ChEBI:CHEBI:15377, ChEBI:CHEBI:17771,
CC         ChEBI:CHEBI:77893; EC=4.2.1.49;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC       Note=Binds 1 NAD(+) per subunit. {ECO:0000250};
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the urocanase family. {ECO:0000305}.
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DR   EMBL; M19665; AAA25078.1; -; Genomic_DNA.
DR   EMBL; M34604; AAA25076.1; -; Genomic_DNA.
DR   UniPathway; UPA00379; UER00550.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016153; F:urocanate hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Cytoplasm; Histidine metabolism; Lyase; NAD.
FT   CHAIN           1..>9
FT                   /note="Urocanate hydratase"
FT                   /id="PRO_0000207341"
FT   NON_TER         9
SQ   SEQUENCE   9 AA;  1140 MW;  970FC41B5325A6C5 CRC64;
     MSQSKYRQL