ID   HV01_CAICR              Reviewed;         117 AA.
AC   P01813;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Ig heavy chain V region C3;
DE   Flags: Precursor;
GN   Name=C3;
OS   Caiman crocodilus (Spectacled caiman) (Caiman sclerops).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Caimaninae; Caiman.
OX   NCBI_TaxID=8499;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6406897; DOI=10.1038/303349a0;
RA   Litman G.W., Berger L., Murphy K., Litman R., Hinds K., Jahn C.L.,
RA   Erickson B.W.;
RT   "Complete nucleotide sequence of an immunoglobulin VH gene homologue from
RT   Caiman, a phylogenetically ancient reptile.";
RL   Nature 303:349-352(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2983316; DOI=10.1073/pnas.82.3.844;
RA   Litman G.W., Murphy K., Berger L., Litman R., Hinds K., Erickson B.W.;
RT   "Complete nucleotide sequences of three VH genes in Caiman, a
RT   phylogenetically ancient reptile: evolutionary diversification in coding
RT   segments and variation in the structure and organization of recombination
RT   elements.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:844-848(1985).
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DR   EMBL; M12768; AAA49192.1; -; Genomic_DNA.
DR   EMBL; V00146; CAA23462.1; -; Genomic_DNA.
DR   PIR; A93302; HVCQ.
DR   AlphaFoldDB; P01813; -.
DR   SMR; P01813; -.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin; Signal.
FT   SIGNAL          1..19
FT   CHAIN           20..117
FT                   /note="Ig heavy chain V region C3"
FT                   /id="PRO_0000015207"
FT   REGION          20..49
FT                   /note="Framework-1"
FT   REGION          50..54
FT                   /note="Complementarity-determining-1"
FT   REGION          55..68
FT                   /note="Framework-2"
FT   REGION          69..85
FT                   /note="Complementarity-determining-2"
FT   REGION          86..117
FT                   /note="Framework-3"
FT   DISULFID        41..115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         117
SQ   SEQUENCE   117 AA;  12628 MW;  482A91C28CDED1E2 CRC64;
     MGLGLHLLVL AAALQGAWSQ VQLVESGGDV RKPGNSLRLS CKASGFTFGG YGMFWVRQAP
     GKGLDWVATI NTDGSSQWYS PAVQGKFTIS RGNSQNMLYL QMSSLTPEDT ATYYCAR