ID   HV01_HETFR              Reviewed;         116 AA.
AC   P03983;
DT   23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-1986, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Ig heavy chain V region;
DE   Flags: Precursor;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE HXIA).
RX   PubMed=3920659; DOI=10.1073/pnas.82.7.2082;
RA   Litman G.W., Berger L., Murphy K., Litman R., Hinds K., Erickson B.W.;
RT   "Immunoglobulin VH gene structure and diversity in Heterodontus, a
RT   phylogenetically primitive shark.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:2082-2086(1985).
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DR   EMBL; M12195; AAA49326.1; -; Genomic_DNA.
DR   PIR; A02086; HVRK.
DR   AlphaFoldDB; P03983; -.
DR   SMR; P03983; -.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin; Signal.
FT   SIGNAL          1..19
FT   CHAIN           20..116
FT                   /note="Ig heavy chain V region"
FT                   /id="PRO_0000015214"
FT   REGION          20..49
FT                   /note="Framework-1"
FT   REGION          50..54
FT                   /note="Complementarity-determining-1"
FT   REGION          55..68
FT                   /note="Framework-2"
FT   REGION          69..84
FT                   /note="Complementarity-determining-2"
FT   REGION          85..116
FT                   /note="Framework-3"
FT   DISULFID        41..114
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         116
SQ   SEQUENCE   116 AA;  13114 MW;  3FF573F04E64D4E4 CRC64;
     MRSAISLSLL LVFLSRVQSD IVLTQPEADT GKPEGSLRLT CKTSGFSLGS YYMTWVRQVP
     GQGLEWLVSY HSSSYQYYAP EIKDRFTASK DTSNNIFALD MKSLKTEDTA MYYCAR