ID   HV02_HETFR              Reviewed;          89 AA.
AC   P04215;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   07-OCT-2020, entry version 64.
DE   RecName: Full=Ig heavy chain V region HC-3;
DE   Flags: Fragment;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3083268; DOI=10.1038/320546a0;
RA   Hinds K.R., Litman G.W.;
RT   "Major reorganization of immunoglobulin VH segmental elements during
RT   vertebrate evolution.";
RL   Nature 320:546-549(1986).
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DR   EMBL; X03748; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A02087; HVRK1.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Immunity; Immunoglobulin.
FT   CHAIN           <1..>89
FT                   /note="Ig heavy chain V region HC-3"
FT                   /id="PRO_0000059858"
FT   REGION          <1..69
FT                   /note="V segment"
FT   REGION          <1..2
FT                   /note="Framework-1"
FT   REGION          3..7
FT                   /note="Complementarity-determining-1"
FT   REGION          8..21
FT                   /note="Framework-2"
FT   REGION          22..37
FT                   /note="Complementarity-determining-2"
FT   REGION          38..69
FT                   /note="Framework-3"
FT   REGION          70..73
FT                   /note="D segment homolog"
FT   REGION          74..89
FT                   /note="J segment homolog"
FT   NON_TER         1
FT   NON_TER         89
SQ   SEQUENCE   89 AA;  10114 MW;  E972E6EA6189C884 CRC64;
     LGSTTMNWVR QGPGXGLEWL VSYYGPSKNA YAPEIKDRFT ASKDTSNNIF ALDMKSLKTE
     DTAIYYCVGQ RNYYYFDFWG QGTMVTVTA