ID   HV03_CARAU              Reviewed;         117 AA.
AC   P19180;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Ig heavy chain V region 3;
DE   Flags: Precursor;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3125551; DOI=10.1073/pnas.85.5.1566;
RA   Wilson M.R., Middleton D., Warr G.W.;
RT   "Immunoglobulin heavy chain variable region gene evolution: structure and
RT   family relationships of two genes and a pseudogene in a teleost fish.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:1566-1570(1988).
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DR   EMBL; J03616; AAA50807.1; -; Genomic_DNA.
DR   PIR; A28966; A28966.
DR   AlphaFoldDB; P19180; -.
DR   SMR; P19180; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT   CHAIN           20..117
FT                   /note="Ig heavy chain V region 3"
FT                   /id="PRO_0000015212"
FT   REGION          20..49
FT                   /note="Framework-1"
FT   REGION          50..54
FT                   /note="Complementarity-determining-1"
FT   REGION          55..68
FT                   /note="Framework-2"
FT   REGION          69..85
FT                   /note="Complementarity-determining-2"
FT   REGION          86..117
FT                   /note="Framework-3"
FT   DISULFID        41..115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         117
SQ   SEQUENCE   117 AA;  13220 MW;  512B625003FA6ECB CRC64;
     MRLWLHLVLL VATLEGVRSQ VQLVESGGDV KKPGDSLRLS CKASGYTFSG YTMYWVRQAP
     GKGLEWVSRI YDDGSDVSYA DTVKGRFTIS RDNAKNLLYL QMSNLKPEDT GRYYCAR