ID   HV05_CARAU              Reviewed;         116 AA.
AC   P19181;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Ig heavy chain V region 5A;
DE   Flags: Precursor;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3125551; DOI=10.1073/pnas.85.5.1566;
RA   Wilson M.R., Middleton D., Warr G.W.;
RT   "Immunoglobulin heavy chain variable region gene evolution: structure and
RT   family relationships of two genes and a pseudogene in a teleost fish.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:1566-1570(1988).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P19181; -.
DR   SMR; P19181; -.
DR   PRIDE; P19181; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT   CHAIN           20..116
FT                   /note="Ig heavy chain V region 5A"
FT                   /id="PRO_0000015213"
FT   REGION          20..49
FT                   /note="Framework-1"
FT   REGION          50..54
FT                   /note="Complementarity-determining-1"
FT   REGION          55..68
FT                   /note="Framework-2"
FT   REGION          69..84
FT                   /note="Complementarity-determining-2"
FT   REGION          85..116
FT                   /note="Framework-3"
FT   DISULFID        41..114
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         116
SQ   SEQUENCE   116 AA;  12808 MW;  9C2279E2DF199B12 CRC64;
     MEFWLSWVFL VAILKGVQCE VQLVESGGGL IQPGGSLRLS CAASGFTVSS NYMSWVRQPP
     GKGLEWVSVI YSGGSTYYAD SVKGRFTISR DNSKNTLYLQ MNSLRAEDTA VYYCAR