ID   HVC3_HETFR              Reviewed;         393 AA.
AC   P23086;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Ig heavy chain C region;
DE   AltName: Full=Clone 6121;
DE   Flags: Fragment;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RX   PubMed=3138109; DOI=10.1002/j.1460-2075.1988.tb03036.x;
RA   Kokubu F., Hinds K., Litman R., Shamblott M.J., Litman G.W.;
RT   "Complete structure and organization of immunoglobulin heavy chain constant
RT   region genes in a phylogenetically primitive vertebrate.";
RL   EMBO J. 7:1979-1988(1988).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X07782; CAA30615.1; -; mRNA.
DR   PIR; S01852; HVRKC1.
DR   AlphaFoldDB; P23086; -.
DR   SMR; P23086; -.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 3.
DR   SMART; SM00407; IGc1; 3.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00290; IG_MHC; 3.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Immunoglobulin domain; Repeat.
FT   CHAIN           <1..393
FT                   /note="Ig heavy chain C region"
FT                   /id="PRO_0000153631"
FT   DOMAIN          63..157
FT                   /note="Ig-like 1"
FT   DOMAIN          168..260
FT                   /note="Ig-like 2"
FT   DOMAIN          270..370
FT                   /note="Ig-like 3"
FT   CARBOHYD        119
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        230
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        329
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        366
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        370
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        380
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   393 AA;  43082 MW;  4E44D076972F18B5 CRC64;
     EPITTGLKTY PSVLNKKGTY TQSSQLTITE SEVGSSKIYC EVRRGESVWI KEIPDCKGDK
     VHPTVILTQS SSEEITSRRF ATVLCSIIDF HPESITVSWL KDGQHMESGF VTSPTCGVNG
     TFSATSRLTV PAREWFTNKV YTCQVSHQGV TQSRNITGSQ VPCSCNDPVI KLLPPSIEQV
     LLEATVTLNC IVSNAPYGVN VSWTQEQKSL KSEIAVQPGE DADSVISTVN ISTQAWLSGA
     EFYCVVNHQD LPTPLRASIH KEEVKDLREP SVSILLSPAE DVSAQRFLSL TCLVRGFSPR
     EIFVKWTIND KSVNPGNYKN TEVMAENDNS SYFIYSLLSI AAEEWASGAS YSCVVGHEAI
     PLKIINRTVN KSSGKPSFVN ISLALLDTVN SCQ