ID   HVCN1_CHICK             Reviewed;         235 AA.
AC   Q5F4C0; Q5ZJ89;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Voltage-gated hydrogen channel 1;
DE   AltName: Full=Hydrogen voltage-gated channel 1;
DE            Short=HV1;
GN   Name=HVCN1; ORFNames=RCJMB04_1c7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Mediates the voltage-dependent proton permeability of
CC       excitable membranes. Forms a proton-selective channel through which
CC       protons may pass in accordance with their electrochemical gradient (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC       characterized by a series of positively charged amino acids at every
CC       third position. Unlike other voltage-gated ion channels it lacks the
CC       pore domain (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The C-terminal coiled coil region mediates homodimerization. It
CC       is essential for normal subcellular localization (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hydrogen channel family. {ECO:0000305}.
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DR   EMBL; AJ720545; CAG32204.1; -; mRNA.
DR   EMBL; AJ851380; CAH65014.1; -; mRNA.
DR   RefSeq; NP_001025834.1; NM_001030663.1.
DR   AlphaFoldDB; Q5F4C0; -.
DR   SMR; Q5F4C0; -.
DR   STRING; 9031.ENSGALP00000007248; -.
DR   PaxDb; Q5F4C0; -.
DR   GeneID; 416871; -.
DR   KEGG; gga:416871; -.
DR   CTD; 84329; -.
DR   VEuPathDB; HostDB:geneid_416871; -.
DR   eggNOG; ENOG502RX8B; Eukaryota.
DR   InParanoid; Q5F4C0; -.
DR   OrthoDB; 1601156at2759; -.
DR   PhylomeDB; Q5F4C0; -.
DR   PRO; PR:Q5F4C0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; ISS:HGNC-UCL.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030171; F:voltage-gated proton channel activity; ISS:HGNC-UCL.
DR   GO; GO:0071467; P:cellular response to pH; ISS:UniProtKB.
DR   GO; GO:0071294; P:cellular response to zinc ion; ISS:UniProtKB.
DR   GO; GO:1902600; P:proton transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0009268; P:response to pH; ISS:HGNC-UCL.
DR   GO; GO:0010043; P:response to zinc ion; ISS:HGNC-UCL.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR031846; Hvcn1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR031844; VGPC1_C.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR46480; PTHR46480; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16799; VGPC1_C; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN           1..235
FT                   /note="Voltage-gated hydrogen channel 1"
FT                   /id="PRO_0000342189"
FT   TOPO_DOM        1..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=Segment S1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        84..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        101..123
FT                   /note="Helical; Name=Segment S2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        124..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=Segment S3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        153..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        160..180
FT                   /note="Helical; Name=Segment S4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        181..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   COILED          187..228
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   235 AA;  27599 MW;  85759D50A3080052 CRC64;
     MSRYLKHFTV VGDDPIQWSN DYQKWENEEE DNGEKDSEIK LEPSRGHVTF QDVMKKLFSS
     RRFQIVIVFL VIVDALLVLG ELLMDLKIIH PDKYHIAPKV FHYLSLSILT IFLVEVGFKI
     FVYGREFFHH KFEVLDSIVV VVSFILDLVL LFREHEFEAV GLLILLRLWR VARIINGIIL
     SVKTRSEQQV SKLKQVNLKL ATKVEQLQHS CVEKEQEIER LTRMLKQHGL LSEQT