ID   HVCN1_DANRE             Reviewed;         235 AA.
AC   Q6DHQ1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Voltage-gated hydrogen channel 1;
DE   AltName: Full=Hydrogen voltage-gated channel 1;
DE            Short=HV1;
GN   Name=hvcn1; ORFNames=zgc:92181;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent proton permeability of
CC       excitable membranes. Forms a proton-selective channel through which
CC       protons may pass in accordance with their electrochemical gradient (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC       characterized by a series of positively charged amino acids at every
CC       third position. Unlike other voltage-gated ion channels it lacks the
CC       pore domain (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The C-terminal coiled coil region mediates homodimerization. It
CC       is essential for normal subcellular localization (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hydrogen channel family. {ECO:0000305}.
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DR   EMBL; BC075916; AAH75916.1; -; mRNA.
DR   RefSeq; NP_001002346.1; NM_001002346.1.
DR   AlphaFoldDB; Q6DHQ1; -.
DR   SMR; Q6DHQ1; -.
DR   STRING; 7955.ENSDARP00000059027; -.
DR   PaxDb; Q6DHQ1; -.
DR   GeneID; 436618; -.
DR   KEGG; dre:436618; -.
DR   CTD; 84329; -.
DR   ZFIN; ZDB-GENE-040718-36; hvcn1.
DR   eggNOG; ENOG502RX8B; Eukaryota.
DR   InParanoid; Q6DHQ1; -.
DR   OrthoDB; 1601156at2759; -.
DR   PhylomeDB; Q6DHQ1; -.
DR   Reactome; R-DRE-1222556; ROS and RNS production in phagocytes.
DR   Reactome; R-DRE-1300642; Sperm Motility And Taxes.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   PRO; PR:Q6DHQ1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:ZFIN.
DR   GO; GO:0030171; F:voltage-gated proton channel activity; IDA:ZFIN.
DR   GO; GO:0008270; F:zinc ion binding; IDA:ZFIN.
DR   GO; GO:0071467; P:cellular response to pH; ISS:UniProtKB.
DR   GO; GO:0071294; P:cellular response to zinc ion; ISS:UniProtKB.
DR   GO; GO:1902600; P:proton transmembrane transport; IDA:ZFIN.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0010043; P:response to zinc ion; IDA:ZFIN.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR031846; Hvcn1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR46480; PTHR46480; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN           1..235
FT                   /note="Voltage-gated hydrogen channel 1"
FT                   /id="PRO_0000342190"
FT   TOPO_DOM        1..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=Segment S1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        87..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        104..126
FT                   /note="Helical; Name=Segment S2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        127..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=Segment S3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        156..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=Segment S4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        184..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   COILED          187..231
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   235 AA;  27110 MW;  D9BCA5D5F1C7F032 CRC64;
     MSRYLKHFTA VGDNKSAVPT WHEEDTSHHV TTLHDAPDGL EVSTGQHLGQ LSFRDSLRKL
     YSTERFQIVV VCLVVLDAIF VLCELLIDLS IIEADHHRIA PQVFHYLSLA LLTFFMVELA
     GKIFAYRLEF LHHKFEVFDG IVVVVSFILD IIYISKEDAF DAMGLLILLR LWRVARIING
     ILVSVQNRAN HRVEKLKEIN ESLVHQVNEL KEQNTKMDQE NVRLRALLKD HSIDF