ID   HVM00_MOUSE             Reviewed;         114 AA.
AC   P01741;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Ig heavy chain V region;
DE   AltName: Full=Anti-arsonate antibody;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=A/J;
RX   PubMed=109536;
RA   Capra J.D., Nisonoff A.;
RT   "Structural studies on induced antibodies with defined idiotypic
RT   specificities. VII. The complete amino acid sequence of the heavy chain
RT   variable region of anti-p-azophenylarsenate antibodies from A/J mice
RT   bearing a cross-reactive idiotype.";
RL   J. Immunol. 123:279-284(1979).
CC   -!- MISCELLANEOUS: Antibody isolated from ten mice was exclusively of the
CC       IgG1 subclass. There was no heterogeneity in the heavy chain V region
CC       sequence.
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DR   PIR; A02022; G1MSAA.
DR   AlphaFoldDB; P01741; -.
DR   SMR; P01741; -.
DR   MaxQB; P01741; -.
DR   PeptideAtlas; P01741; -.
DR   PRIDE; P01741; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01741; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Direct protein sequencing; Immunity; Immunoglobulin;
KW   Reference proteome.
FT   CHAIN           1..>114
FT                   /note="Ig heavy chain V region"
FT                   /id="PRO_0000059867"
FT   DOMAIN          1..106
FT                   /note="Ig-like"
FT   NON_TER         114
SQ   SEQUENCE   114 AA;  12555 MW;  99DD8F0B6A69F4BE CRC64;
     EVQLQQSGAE LVKAGSSVKM SCKATGYTFS SYELYWVRQA PGQGLEDLGY ISSSSAYPNY
     AQKFQGRVTI TADESTNTAY MELSSLRSED TAVYFCAVRV ISRYFDGWGQ GTLV