HVM03_MOUSE
ID HVM03_MOUSE Reviewed; 120 AA.
AC P01747;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Ig heavy chain V region 36-65;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6186498; DOI=10.1002/eji.1830121208;
RA Siekevitz M., Gefter M.L., Brodeur P., Riblet R., Marshak-Rothstein A.;
RT "The genetic basis of antibody production: the dominant anti-arsonate
RT idiotype response of the strain A mouse.";
RL Eur. J. Immunol. 12:1023-1032(1982).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-120.
RX PubMed=11673524; DOI=10.4049/jimmunol.167.9.5129;
RA Parhami-Seren B., Viswanathan M., Strong R.K., Margolies M.N.;
RT "Structural analysis of mutants of high-affinity and low-affinity p-
RT azophenylarsonate-specific antibodies generated by alanine scanning of
RT heavy chain complementarity-determining region 2.";
RL J. Immunol. 167:5129-5135(2001).
CC -!- MISCELLANEOUS: From analysis of the sizes of several other
CC differentiated genes that hybridize to this one, the authors conclude
CC that all of these V regions have rearranged to the same J segment, JH2.
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DR PIR; A28572; A28572.
DR PIR; A94264; HVMSG7.
DR PIR; PH1487; PH1487.
DR PIR; PH1490; PH1490.
DR PIR; PH1491; PH1491.
DR PDB; 1JFQ; X-ray; 1.90 A; H=1-120.
DR PDBsum; 1JFQ; -.
DR AlphaFoldDB; P01747; -.
DR SMR; P01747; -.
DR MINT; P01747; -.
DR MaxQB; P01747; -.
DR PeptideAtlas; P01747; -.
DR PRIDE; P01747; -.
DR EvolutionaryTrace; P01747; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01747; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Hybridoma; Immunity; Immunoglobulin;
KW Reference proteome.
FT CHAIN 1..>120
FT /note="Ig heavy chain V region 36-65"
FT /id="PRO_0000059869"
FT DOMAIN 1..111
FT /note="Ig-like"
FT NON_TER 120
FT STRAND 2..7
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 17..26
FT /evidence="ECO:0007829|PDB:1JFQ"
FT HELIX 28..30
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 33..38
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 40..42
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 44..51
FT /evidence="ECO:0007829|PDB:1JFQ"
FT TURN 52..55
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 56..59
FT /evidence="ECO:0007829|PDB:1JFQ"
FT TURN 61..63
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:1JFQ"
FT TURN 73..76
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 77..82
FT /evidence="ECO:0007829|PDB:1JFQ"
FT HELIX 87..89
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 91..101
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 104..110
FT /evidence="ECO:0007829|PDB:1JFQ"
FT STRAND 114..118
FT /evidence="ECO:0007829|PDB:1JFQ"
SQ SEQUENCE 120 AA; 13307 MW; FF04E4A167B654AF CRC64;
VQLQQSGAEL VRAGSSVKMS CKASGYTFTS YGINWVKQRP GQGLEWIGYI NPGNGYTKYN
EKFKGKTTLT VDKSSSTAYM QLRSLTSEDS AVYFCARSVY YGGSYYFDYW GQGTTLTVSS
