HVM10_MOUSE
ID HVM10_MOUSE Reviewed; 117 AA.
AC P01754; P11270;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Ig heavy chain V region 1-62-3;
DE AltName: Full=Ig heavy chain V region 145;
DE Flags: Precursor;
GN Name=Ighv1-62-3; Synonyms=Igh-VJ558;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=6788376; DOI=10.1016/0092-8674(81)90089-1;
RA Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K.,
RA Baltimore D.;
RT "Heavy chain variable region contribution to the NPb family of antibodies:
RT somatic mutation evident in a gamma 2a variable region.";
RL Cell 24:625-637(1981).
CC -!- MISCELLANEOUS: This germline gene belongs to a set of closely related
CC genes that could encode V regions of NPb antibodies.
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DR EMBL; J00533; AAA38602.1; -; Genomic_DNA.
DR PIR; C90809; HVMS45.
DR AlphaFoldDB; P01754; -.
DR SMR; P01754; -.
DR MaxQB; P01754; -.
DR PeptideAtlas; P01754; -.
DR PRIDE; P01754; -.
DR ProteomicsDB; 273212; -.
DR Ensembl; ENSMUST00000103532; ENSMUSP00000100313; ENSMUSG00000096767.
DR MGI; MGI:3648544; Ighv1-62-3.
DR VEuPathDB; HostDB:ENSMUSG00000096767; -.
DR GeneTree; ENSGT00950000183013; -.
DR HOGENOM; CLU_077975_5_2_1; -.
DR InParanoid; P01754; -.
DR OMA; EWIGWIV; -.
DR PhylomeDB; P01754; -.
DR TreeFam; TF336708; -.
DR Reactome; R-MMU-166663; Initial triggering of complement.
DR Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-MMU-2029481; FCGR activation.
DR Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR Reactome; R-MMU-977606; Regulation of Complement cascade.
DR Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR PRO; PR:P01754; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P01754; protein.
DR Bgee; ENSMUSG00000096767; Expressed in granulocyte and 7 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Adaptive immunity; Immunity; Immunoglobulin; Reference proteome; Signal.
FT SIGNAL 1..19
FT CHAIN 20..117
FT /note="Ig heavy chain V region 1-62-3"
FT /id="PRO_0000015222"
FT REGION 20..49
FT /note="Framework-1"
FT REGION 50..54
FT /note="Complementarity-determining-1"
FT REGION 55..68
FT /note="Framework-2"
FT REGION 69..85
FT /note="Complementarity-determining-2"
FT REGION 86..117
FT /note="Framework-3"
FT NON_TER 117
SQ SEQUENCE 117 AA; 12921 MW; D37DE8A3F543E996 CRC64;
MGWSCIMLFL AATATGVHFQ VQLQQPGAEL VKPGASVKLS SKASGYTFTS YWMHWVKQRP
GRGLEWIGRI DPNSGGTKYN EKFKSKATLT VDKPSSTAYM QLSSLTSEDS AVYYCAR
