ID   HVM12_MOUSE             Reviewed;         117 AA.
AC   P01756;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Ig heavy chain V region MOPC 104E;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE, AND GLYCOSYLATION AT ASN-55.
RX   PubMed=6816276; DOI=10.1021/bi00265a006;
RA   Kehry M.R., Fuhrman J.S., Schilling J.W., Rogers J., Sibley C.H.,
RA   Hood L.E.;
RT   "Complete amino acid sequence of a mouse mu chain: homology among heavy
RT   chain constant region domains.";
RL   Biochemistry 21:5415-5424(1982).
CC   -!- MISCELLANEOUS: The sequence of the light chain of this IgM myeloma
CC       protein has also been determined.
CC   -!- MISCELLANEOUS: This protein binds dextran.
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DR   PIR; A02039; MHMS4E.
DR   PDB; 3BQU; X-ray; 3.00 A; D=2-98.
DR   PDBsum; 3BQU; -.
DR   AlphaFoldDB; P01756; -.
DR   SMR; P01756; -.
DR   GlyGen; P01756; 1 site.
DR   iPTMnet; P01756; -.
DR   MaxQB; P01756; -.
DR   PeptideAtlas; P01756; -.
DR   PRIDE; P01756; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01756; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Immunity; Immunoglobulin; Reference proteome.
FT   CHAIN           1..>117
FT                   /note="Ig heavy chain V region MOPC 104E"
FT                   /id="PRO_0000059870"
FT   DOMAIN          1..116
FT                   /note="Ig-like"
FT   CARBOHYD        55
FT                   /note="N-linked (GlcNAc...) (high mannose) asparagine;
FT                   atypical"
FT                   /evidence="ECO:0000269|PubMed:6816276"
FT   DISULFID        22..96
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         117
FT   STRAND          4..6
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          10..12
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          18..23
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   HELIX           29..31
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          34..40
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          46..51
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          53..55
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          58..60
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   TURN            62..67
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          68..73
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   HELIX           74..76
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          78..83
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   HELIX           88..90
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          92..98
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   TURN            101..103
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          105..108
FT                   /evidence="ECO:0007829|PDB:3BQU"
FT   STRAND          111..115
FT                   /evidence="ECO:0007829|PDB:3BQU"
SQ   SEQUENCE   117 AA;  12983 MW;  3CF8ACE4BE447E41 CRC64;
     EVQLQQSGPE LVKPGASVKM SCKASGYTFT DYYMKWVKQS HGKSLEWIGD INPNNGGTSY
     NQKFKGKATL TVDKSSSTAY MQLNSLTSED SAVYYCARDY DWYFDVWGAG TTVTVSS