HVM13_MOUSE
ID HVM13_MOUSE Reviewed; 117 AA.
AC P01757;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Ig heavy chain V region J558;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=6765983; DOI=10.1038/283035a0;
RA Schilling J., Clevinger B., Davie J.M., Hood L.;
RT "Amino acid sequence of homogeneous antibodies to dextran and DNA
RT rearrangements in heavy chain V-region gene segments.";
RL Nature 283:35-40(1980).
CC -!- MISCELLANEOUS: The sequences of 10 hybridoma proteins that also bind
CC dextran differ from that shown at 1-7 positions, many of which occur in
CC the D and J segments.
CC -!- MISCELLANEOUS: This protein binds dextran.
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DR PIR; A26242; MHMSJ5.
DR PDB; 2OZ4; X-ray; 2.70 A; H=1-97.
DR PDBsum; 2OZ4; -.
DR AlphaFoldDB; P01757; -.
DR SMR; P01757; -.
DR EPD; P01757; -.
DR MaxQB; P01757; -.
DR PRIDE; P01757; -.
DR EvolutionaryTrace; P01757; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01757; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Direct protein sequencing; Disulfide bond;
KW Immunity; Immunoglobulin; Reference proteome.
FT CHAIN 1..>117
FT /note="Ig heavy chain V region J558"
FT /id="PRO_0000059871"
FT DOMAIN 1..116
FT /note="Ig-like"
FT DISULFID 22..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 117
FT STRAND 3..6
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 10..12
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 18..27
FT /evidence="ECO:0007829|PDB:2OZ4"
FT TURN 29..31
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 34..39
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:2OZ4"
FT TURN 53..55
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 58..60
FT /evidence="ECO:0007829|PDB:2OZ4"
FT HELIX 62..64
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 68..73
FT /evidence="ECO:0007829|PDB:2OZ4"
FT TURN 74..77
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 78..83
FT /evidence="ECO:0007829|PDB:2OZ4"
FT HELIX 88..90
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 92..98
FT /evidence="ECO:0007829|PDB:2OZ4"
FT TURN 99..102
FT /evidence="ECO:0007829|PDB:2OZ4"
FT STRAND 111..115
FT /evidence="ECO:0007829|PDB:2OZ4"
SQ SEQUENCE 117 AA; 13025 MW; 292E2AF4BE447E41 CRC64;
EVQLQQSGPE LVKPGASVKM SCKASGYTFT DYYMKWVKQS HGKSLEWIGD INPNNGGTSY
NQKFKGKATL TVDKSSSTAY MQLNSLTSED SAVYYCARDR YWYFDVWGAG TTVTVSS
