ID   HVM18_MOUSE             Reviewed;         123 AA.
AC   P01787;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Ig heavy chain V regions TEPC 15/S107/HPCM1/HPCM2/HPCM3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE (TEPC 15).
RX   PubMed=819932; DOI=10.1073/pnas.73.6.2109;
RA   Rudikoff S., Potter M.;
RT   "Size differences among immunoglobulin heavy chains from phosphorylcholine-
RT   binding proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 73:2109-2112(1976).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (H107).
RX   PubMed=6769593; DOI=10.1016/0092-8674(80)90089-6;
RA   Early P., Huang H., Davis M., Calame K., Hood L.;
RT   "An immunoglobulin heavy chain variable region gene is generated from three
RT   segments of DNA: VH, D and JH.";
RL   Cell 19:981-992(1980).
RN   [3]
RP   PROTEIN SEQUENCE (S107).
RX   PubMed=813561; DOI=10.1146/annurev.ge.09.120175.001513;
RA   Hood L., Campbell J.H., Elgin S.C.R.;
RT   "The organization, expression, and evolution of antibody genes and other
RT   multigene families.";
RL   Annu. Rev. Genet. 9:305-353(1975).
RN   [4]
RP   PROTEIN SEQUENCE (HPCM1; HPCM2 AND HPCM3).
RX   PubMed=7231520; DOI=10.1038/291029a0;
RA   Gearhart P.J., Johnson N.D., Douglas R., Hood L.;
RT   "IgG antibodies to phosphorylcholine exhibit more diversity than their IgM
RT   counterparts.";
RL   Nature 291:29-34(1981).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3141511;
RA   Claflin J.L., Berry J.;
RT   "Genetics of the phosphocholine-specific antibody response to Streptococcus
RT   pneumoniae. Germ-line but not mutated T15 antibodies are dominantly
RT   selected.";
RL   J. Immunol. 141:4012-4019(1988).
CC   -!- MISCELLANEOUS: All those sequence appears to be identical.
CC   -!- MISCELLANEOUS: These chains were isolated from myeloma and hybridoma
CC       proteins that bind phosphorylcholine.
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DR   PIR; A30515; A30515.
DR   PIR; A30539; A30539.
DR   PIR; A30556; A30556.
DR   PIR; A93804; AVMST5.
DR   PIR; B30540; B30540.
DR   PIR; B30556; B30556.
DR   PIR; B93857; AVMS51.
DR   PIR; C30540; C30540.
DR   PIR; D30539; D30539.
DR   PIR; D30556; D30556.
DR   PIR; E30539; E30539.
DR   PIR; F30539; F30539.
DR   PIR; G30539; G30539.
DR   PIR; H30535; H30535.
DR   PIR; H30539; H30539.
DR   PIR; I30535; I30535.
DR   PIR; I30538; I30538.
DR   PIR; PL0017; PL0017.
DR   PIR; PT0353; PT0353.
DR   PIR; PT0354; PT0354.
DR   AlphaFoldDB; P01787; -.
DR   SMR; P01787; -.
DR   MaxQB; P01787; -.
DR   PeptideAtlas; P01787; -.
DR   PRIDE; P01787; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01787; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Direct protein sequencing; Hybridoma; Immunity;
KW   Immunoglobulin; Reference proteome.
FT   CHAIN           1..>123
FT                   /note="Ig heavy chain V regions TEPC
FT                   15/S107/HPCM1/HPCM2/HPCM3"
FT                   /id="PRO_0000059873"
FT   DOMAIN          1..114
FT                   /note="Ig-like"
FT   NON_TER         123
SQ   SEQUENCE   123 AA;  13777 MW;  9D58086DE12F7000 CRC64;
     EVKLVESGGG LVQPGGSLRL SCATSGFTFS DFYMEWVRQP PGKRLEWIAA SRNKANDYTT
     EYSASVKGRF IVSRDTSQSI LYLQMNALRA EDTAIYYCAR DYYGSSYWYF DVWGAGTTVT
     VSS