HVM26_MOUSE
ID HVM26_MOUSE Reviewed; 144 AA.
AC P01795;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Ig heavy chain V region M167;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6101208; DOI=10.1016/0092-8674(81)90399-8;
RA Kim S., Davis M., Sinn E., Patten P., Hood L.;
RT "Antibody diversity: somatic hypermutation of rearranged VH genes.";
RL Cell 27:573-581(1981).
RN [2]
RP PROTEIN SEQUENCE OF 20-142.
RX PubMed=819932; DOI=10.1073/pnas.73.6.2109;
RA Rudikoff S., Potter M.;
RT "Size differences among immunoglobulin heavy chains from phosphorylcholine-
RT binding proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 73:2109-2112(1976).
CC -!- MISCELLANEOUS: This chain was isolated from an IgA myeloma protein that
CC binds phosphorylcholine.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; J00516; AAC18867.2; ALT_TERM; Genomic_DNA.
DR PIR; A90818; AVMS67.
DR AlphaFoldDB; P01795; -.
DR SMR; P01795; -.
DR PRIDE; P01795; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01795; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Direct protein sequencing; Immunity; Immunoglobulin;
KW Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:819932"
FT CHAIN 20..144
FT /note="Ig heavy chain V region M167"
FT /id="PRO_0000015227"
FT DOMAIN 20..133
FT /note="Ig-like"
FT CONFLICT 125
FT /note="N -> D (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT NON_TER 144
SQ SEQUENCE 144 AA; 16219 MW; BECB4A2C956CF769 CRC64;
MKMWLNWVFL LTLLHGIQCE VKVVESGGGL VQPGGSLRLS CATSGFTFSD FYMEWVRQTP
GKRLEWIAAS RSKAHDYRTE YSASVKGRFI VSRDTSQSVL YLQMNALRAE DTATYYCTRD
ADYGNSYFGY FDVWGAGTTV TVSS
