HVM38_MOUSE
ID HVM38_MOUSE Reviewed; 119 AA.
AC P01808;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Ig heavy chain V region T601;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=111245; DOI=10.1073/pnas.76.6.2890;
RA Rao D.N., Rudikoff S., Krutzsch H., Potter M.;
RT "Structural evidence for independent joining region gene in immunoglobulin
RT heavy chains from anti-galactan myeloma proteins and its potential role in
RT generating diversity in complementarity-determining regions.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:2890-2894(1979).
CC -!- MISCELLANEOUS: This chain was isolated from an IgA myeloma protein that
CC binds galactan.
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DR PIR; A02078; AVMST6.
DR PDB; 1OTS; X-ray; 2.51 A; C/E=1-118.
DR PDB; 1OTT; X-ray; 3.00 A; C/E=1-118.
DR PDB; 1OTU; X-ray; 3.30 A; C/E=1-118.
DR PDB; 2EXW; X-ray; 3.20 A; C/E=1-118.
DR PDB; 2EXY; X-ray; 3.10 A; C/E=1-118.
DR PDB; 2EZ0; X-ray; 3.54 A; C/E=1-118.
DR PDB; 2H2P; X-ray; 3.10 A; C/E=2-118.
DR PDB; 2H2S; X-ray; 3.10 A; C/E=2-118.
DR PDB; 2HLF; X-ray; 3.30 A; C/E=2-118.
DR PDB; 2HT2; X-ray; 3.32 A; C/E=2-118.
DR PDB; 2HT3; X-ray; 3.30 A; C/E=2-118.
DR PDB; 2HT4; X-ray; 3.20 A; C/E=2-118.
DR PDB; 2HTK; X-ray; 3.41 A; C/E=2-118.
DR PDB; 2HTL; X-ray; 3.40 A; C/E=2-118.
DR PDB; 3DET; X-ray; 2.80 A; C/E=2-118.
DR PDB; 3EJY; X-ray; 3.20 A; C/E=2-118.
DR PDB; 3EJZ; X-ray; 2.90 A; C/E=2-118.
DR PDB; 3U0W; X-ray; 2.00 A; H=1-98.
DR PDB; 4KKB; X-ray; 3.02 A; C/E=1-118.
DR PDB; 4MQX; X-ray; 3.52 A; C/E=1-118.
DR PDBsum; 1OTS; -.
DR PDBsum; 1OTT; -.
DR PDBsum; 1OTU; -.
DR PDBsum; 2EXW; -.
DR PDBsum; 2EXY; -.
DR PDBsum; 2EZ0; -.
DR PDBsum; 2H2P; -.
DR PDBsum; 2H2S; -.
DR PDBsum; 2HLF; -.
DR PDBsum; 2HT2; -.
DR PDBsum; 2HT3; -.
DR PDBsum; 2HT4; -.
DR PDBsum; 2HTK; -.
DR PDBsum; 2HTL; -.
DR PDBsum; 3DET; -.
DR PDBsum; 3EJY; -.
DR PDBsum; 3EJZ; -.
DR PDBsum; 3U0W; -.
DR PDBsum; 4KKB; -.
DR PDBsum; 4MQX; -.
DR AlphaFoldDB; P01808; -.
DR SMR; P01808; -.
DR MaxQB; P01808; -.
DR PRIDE; P01808; -.
DR MGI; MGI:96461; Igh-J.
DR InParanoid; P01808; -.
DR EvolutionaryTrace; P01808; -.
DR PRO; PR:P01808; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01808; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Direct protein sequencing; Immunity;
KW Immunoglobulin; Reference proteome.
FT CHAIN 1..>119
FT /note="Ig heavy chain V region T601"
FT /id="PRO_0000059891"
FT DOMAIN 1..112
FT /note="Ig-like"
FT NON_TER 119
FT STRAND 3..7
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 10..12
FT /evidence="ECO:0007829|PDB:1OTS"
FT STRAND 18..27
FT /evidence="ECO:0007829|PDB:3U0W"
FT HELIX 29..31
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 34..39
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 58..60
FT /evidence="ECO:0007829|PDB:3U0W"
FT HELIX 62..64
FT /evidence="ECO:0007829|PDB:3U0W"
FT TURN 65..67
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 68..73
FT /evidence="ECO:0007829|PDB:3U0W"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 78..83
FT /evidence="ECO:0007829|PDB:3U0W"
FT HELIX 88..90
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 92..98
FT /evidence="ECO:0007829|PDB:3U0W"
FT TURN 101..103
FT /evidence="ECO:0007829|PDB:3U0W"
FT STRAND 105..108
FT /evidence="ECO:0007829|PDB:4KKB"
FT STRAND 112..116
FT /evidence="ECO:0007829|PDB:3U0W"
SQ SEQUENCE 119 AA; 13169 MW; BC38CC84E6EA00E8 CRC64;
EVKLLESGGG LVQPGGSLKL SCAASGFDFS RYWMSWVRQA PGKGLEWIGE INPDSSTINY
TPSLKDKFII SRDNAKNTLY LQMSKVRSED TALYYCARLG YYGYFDVWGA GTTVTVSSE
