ID   HVM40_MOUSE             Reviewed;         119 AA.
AC   P01810;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Ig heavy chain V region J539;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PRELIMINARY PROTEIN SEQUENCE.
RX   PubMed=111245; DOI=10.1073/pnas.76.6.2890;
RA   Rao D.N., Rudikoff S., Krutzsch H., Potter M.;
RT   "Structural evidence for independent joining region gene in immunoglobulin
RT   heavy chains from anti-galactan myeloma proteins and its potential role in
RT   generating diversity in complementarity-determining regions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:2890-2894(1979).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
RX   PubMed=3449853; DOI=10.1002/prot.340010112;
RA   Suh S.W., Bhat T.N., Navia M.A., Cohen G.H., Rao D.N., Rudikoff S.,
RA   Davies D.R.;
RT   "The galactan-binding immunoglobulin Fab J539: an X-ray diffraction study
RT   at 2.6-A resolution.";
RL   Proteins 1:74-80(1986).
CC   -!- MISCELLANEOUS: This chain was isolated from a myeloma protein that
CC       binds galactan.
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DR   PIR; A02080; AVMSJ5.
DR   PDB; 2FBJ; X-ray; 1.95 A; H=1-119.
DR   PDBsum; 2FBJ; -.
DR   AlphaFoldDB; P01810; -.
DR   SMR; P01810; -.
DR   GlyGen; P01810; 1 site.
DR   MaxQB; P01810; -.
DR   PRIDE; P01810; -.
DR   EvolutionaryTrace; P01810; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01810; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Direct protein sequencing; Immunity;
KW   Immunoglobulin; Reference proteome.
FT   CHAIN           1..>119
FT                   /note="Ig heavy chain V region J539"
FT                   /id="PRO_0000059893"
FT   NON_TER         119
FT   STRAND          3..7
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          10..12
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          18..27
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   HELIX           29..31
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          34..39
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          45..51
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          58..60
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   TURN            62..67
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          68..72
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          74..76
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          78..83
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   HELIX           88..90
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          92..100
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   TURN            101..103
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          104..108
FT                   /evidence="ECO:0007829|PDB:2FBJ"
FT   STRAND          112..116
FT                   /evidence="ECO:0007829|PDB:2FBJ"
SQ   SEQUENCE   119 AA;  13240 MW;  577B4F1DB675C1F1 CRC64;
     EVKLLESGGG LVQPGGSLKL SCAASGFDFS KYWMSWVRQA PGKGLEWIGE IHPDSGTINY
     TPSLKDKFII SRDNAKNSLY LQMSKVRSED TALYYCARLH YYGYNAYWGQ GTLVTVSAE