ID   HVM42_MOUSE             Reviewed;         117 AA.
AC   P01812;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Ig heavy chain V region MOPC 173;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-104.
RX   PubMed=5062012; DOI=10.1111/j.1432-1033.1972.tb19705.x;
RA   Bourgois A., Fougereau M., de Preval C.;
RT   "Sequence of amino acids of the NH 2 -terminal region of a mouse-clonal
RT   immunoglobulin heavy chain.";
RL   Eur. J. Biochem. 24:446-455(1972).
RN   [2]
RP   PROTEIN SEQUENCE OF 105-117.
RX   PubMed=812695; DOI=10.1111/j.1432-1033.1975.tb02478.x;
RA   Rocca-Serra J., Milili M., Fougereau M.;
RT   "Determination of the primary structure of a mouse IgG2a immunoglobulin.
RT   Amino-acid sequence of the H4 cyanogen-bromide fragment.";
RL   Eur. J. Biochem. 59:511-523(1975).
RN   [3]
RP   NUCLEOTIDE SEQUENCE OF 96-117.
RX   PubMed=6787590; DOI=10.1073/pnas.78.1.509;
RA   Gough N.M., Bernard O.;
RT   "Sequences of the joining region genes for immunoglobulin heavy chains and
RT   their role in generation of antibody diversity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:509-513(1981).
RN   [4]
RP   DISULFIDE BOND.
RX   PubMed=11947590; DOI=10.1016/0014-5793(70)80283-6;
RA   Bourgois A., Fougereau M.;
RT   "Partial amino acid sequence of the variable region of a mouse gammaG2a
RT   immunoglobulin heavy chain. Evidence for the existence of a third sub-group
RT   of variability for the heavy chain pool.";
RL   FEBS Lett. 8:265-268(1970).
CC   -!- MISCELLANEOUS: This gamma-2a chain was isolated from a myeloma protein.
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DR   PIR; A91190; G2MS73.
DR   AlphaFoldDB; P01812; -.
DR   SMR; P01812; -.
DR   MaxQB; P01812; -.
DR   PRIDE; P01812; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01812; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Direct protein sequencing; Disulfide bond; Immunity;
KW   Immunoglobulin; Reference proteome.
FT   CHAIN           1..>117
FT                   /note="Ig heavy chain V region MOPC 173"
FT                   /id="PRO_0000059895"
FT   DOMAIN          1..116
FT                   /note="Ig-like"
FT   DISULFID        22..96
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:11947590"
FT   CONFLICT        105
FT                   /note="N -> D (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         117
SQ   SEQUENCE   117 AA;  13051 MW;  156DCCC259380F19 CRC64;
     EVKLLESGGP LVQLGGSLKL SCAASGFDFS RYWMSWVRQA PGKGLEWIGE IDPNSSTINY
     TPSLKDKFII SRNDAKNTLY LQMSKVRSED TALYYCARSP YYAMNYWGQG TSVTVSS