ID   HVM43_MOUSE             Reviewed;         144 AA.
AC   P01819;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Ig heavy chain V region MOPC 141;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6774258; DOI=10.1038/286676a0;
RA   Sakano H., Maki R., Kurosawa Y., Roeder W., Tonegawa S.;
RT   "Two types of somatic recombination are necessary for the generation of
RT   complete immunoglobulin heavy-chain genes.";
RL   Nature 286:676-683(1980).
CC   -!- MISCELLANEOUS: The sequence shown is translated from a differentiated
CC       gene isolated from a myeloma that secretes IgG2b.
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DR   EMBL; AH001932; AAA38121.1; -; Genomic_DNA.
DR   PIR; A02094; G2MS14.
DR   AlphaFoldDB; P01819; -.
DR   SMR; P01819; -.
DR   MaxQB; P01819; -.
DR   PRIDE; P01819; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01819; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Immunity; Immunoglobulin; Reference proteome; Signal.
FT   SIGNAL          1..19
FT   CHAIN           20..144
FT                   /note="Ig heavy chain V region MOPC 141"
FT                   /id="PRO_0000015229"
FT   DOMAIN          20..130
FT                   /note="Ig-like"
FT   NON_TER         144
SQ   SEQUENCE   144 AA;  15759 MW;  8E47A7CB3706D30A CRC64;
     MAVLALLFCL ATFPSCILSQ VQLKESGPGL VAPSQSLSIT CTVSGFSLTG YGVNWVRQPP
     GKGLEWLGTI WGNGSTDYNS TLKSRLTITK DNSKSQVFLK MNSLQTDDTA RYYCASVSIY
     YYGRSDKYFT LDYWGQGTSV TVSS