HVM44_MOUSE
ID HVM44_MOUSE Reviewed; 115 AA.
AC P01820;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Ig heavy chain V region PJ14;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6774258; DOI=10.1038/286676a0;
RA Sakano H., Maki R., Kurosawa Y., Roeder W., Tonegawa S.;
RT "Two types of somatic recombination are necessary for the generation of
RT complete immunoglobulin heavy-chain genes.";
RL Nature 286:676-683(1980).
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DR EMBL; V00767; CAA24148.1; -; Genomic_DNA.
DR PIR; A02095; HVMS14.
DR PDB; 1A2Y; X-ray; 1.50 A; B=20-115.
DR PDB; 1A7N; X-ray; 2.01 A; H=20-115.
DR PDB; 1A7O; X-ray; 2.00 A; H=20-115.
DR PDB; 1A7P; X-ray; 2.01 A; H=20-115.
DR PDB; 1A7Q; X-ray; 2.00 A; H=20-115.
DR PDB; 1A7R; X-ray; 2.01 A; H=20-115.
DR PDB; 1DL7; X-ray; 2.35 A; H=20-115.
DR PDB; 1DVF; X-ray; 1.90 A; B=20-115.
DR PDB; 1G7H; X-ray; 1.85 A; B=20-115.
DR PDB; 1G7I; X-ray; 1.80 A; B=20-115.
DR PDB; 1G7J; X-ray; 1.75 A; B=20-115.
DR PDB; 1G7L; X-ray; 2.00 A; B=20-115.
DR PDB; 1G7M; X-ray; 1.90 A; B=20-115.
DR PDB; 1KIR; X-ray; 2.00 A; B=20-115.
DR PDB; 1P4B; X-ray; 2.35 A; H=21-114.
DR PDB; 1P4I; X-ray; 2.80 A; H=21-114.
DR PDB; 1VFA; X-ray; 1.80 A; B=20-115.
DR PDB; 1VFB; X-ray; 1.80 A; B=20-115.
DR PDB; 43C9; X-ray; 2.20 A; B/D/F/H=20-114.
DR PDB; 43CA; X-ray; 2.30 A; B/D/F/H=20-114.
DR PDBsum; 1A2Y; -.
DR PDBsum; 1A7N; -.
DR PDBsum; 1A7O; -.
DR PDBsum; 1A7P; -.
DR PDBsum; 1A7Q; -.
DR PDBsum; 1A7R; -.
DR PDBsum; 1DL7; -.
DR PDBsum; 1DVF; -.
DR PDBsum; 1G7H; -.
DR PDBsum; 1G7I; -.
DR PDBsum; 1G7J; -.
DR PDBsum; 1G7L; -.
DR PDBsum; 1G7M; -.
DR PDBsum; 1KIR; -.
DR PDBsum; 1P4B; -.
DR PDBsum; 1P4I; -.
DR PDBsum; 1VFA; -.
DR PDBsum; 1VFB; -.
DR PDBsum; 43C9; -.
DR PDBsum; 43CA; -.
DR AlphaFoldDB; P01820; -.
DR SMR; P01820; -.
DR IntAct; P01820; 1.
DR MINT; P01820; -.
DR MaxQB; P01820; -.
DR PRIDE; P01820; -.
DR EvolutionaryTrace; P01820; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01820; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Immunity; Immunoglobulin;
KW Reference proteome; Signal.
FT SIGNAL 1..19
FT CHAIN 20..115
FT /note="Ig heavy chain V region PJ14"
FT /id="PRO_0000015230"
FT DOMAIN 20..>115
FT /note="Ig-like"
FT NON_TER 115
FT STRAND 22..26
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 29..31
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 37..46
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 50..58
FT /evidence="ECO:0007829|PDB:1A2Y"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:43C9"
FT STRAND 65..70
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:43C9"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:1A2Y"
FT TURN 80..82
FT /evidence="ECO:0007829|PDB:1A2Y"
FT HELIX 83..85
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 86..91
FT /evidence="ECO:0007829|PDB:1A2Y"
FT HELIX 92..94
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 96..101
FT /evidence="ECO:0007829|PDB:1A2Y"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:1A2Y"
FT STRAND 110..115
FT /evidence="ECO:0007829|PDB:1A2Y"
SQ SEQUENCE 115 AA; 12447 MW; 7569DD4A4843D500 CRC64;
MAVLALLFCL VTFPSCILSQ VQLKESGPGL VAPSQSLSIT CTVSGFSLTG YGVNWVRQPP
GKGLEWLGMI WGDGSTDYNS ALKSRLSISK DNSKSQVFLK MNSLQTDDTA RYYCA
