HVM45_MOUSE
ID HVM45_MOUSE Reviewed; 116 AA.
AC P01821;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Ig heavy chain V region MC101;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6273429; DOI=10.1016/s0021-9258(19)68358-4;
RA Kataoka T., Nikaido T., Miyata T., Moriwaki K., Honjo T.;
RT "The nucleotide sequences of rearranged and germline immunoglobulin VH
RT genes of a mouse myeloma MC101 and evolution of VH genes in mouse.";
RL J. Biol. Chem. 257:277-285(1982).
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DR EMBL; J00502; AAA38515.1; -; Genomic_DNA.
DR PIR; A02096; G1MS10.
DR PIR; A25913; A25913.
DR PIR; A33932; A33932.
DR PDB; 1T2Q; X-ray; 1.83 A; H=26-116.
DR PDBsum; 1T2Q; -.
DR AlphaFoldDB; P01821; -.
DR SMR; P01821; -.
DR PRIDE; P01821; -.
DR MGI; MGI:3643263; EG668389.
DR InParanoid; P01821; -.
DR EvolutionaryTrace; P01821; -.
DR PRO; PR:P01821; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01821; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Immunity; Immunoglobulin;
KW Reference proteome; Signal.
FT SIGNAL 1..19
FT CHAIN 20..116
FT /note="Ig heavy chain V region MC101"
FT /id="PRO_0000015231"
FT DOMAIN 20..>116
FT /note="Ig-like"
FT NON_TER 116
FT STRAND 23..26
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 29..31
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 37..46
FT /evidence="ECO:0007829|PDB:1T2Q"
FT TURN 48..50
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 53..59
FT /evidence="ECO:0007829|PDB:1T2Q"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 63..70
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:1T2Q"
FT TURN 80..85
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 86..91
FT /evidence="ECO:0007829|PDB:1T2Q"
FT TURN 92..95
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 96..101
FT /evidence="ECO:0007829|PDB:1T2Q"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:1T2Q"
FT STRAND 110..116
FT /evidence="ECO:0007829|PDB:1T2Q"
SQ SEQUENCE 116 AA; 12593 MW; 8079A6EE7C552B3E CRC64;
MAVLGLLFCL VTFPSCVLSQ VQLKQSGPGL VQPSQSLSIT CTVSGFSLTS YGVHWVRQSP
GKGLEWLGVI WSGGSTDYNA AFISRLSISK DNSKSQVFFK MNSLQSNDTA IYYCAR
