ID   HVM48_MOUSE             Reviewed;         138 AA.
AC   P03980;
DT   23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-1986, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Ig heavy chain V region TEPC 1017;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=6429663; DOI=10.1073/pnas.81.13.4164;
RA   Gilliam A.C., Shen A., Richards J.E., Blattner F.R., Mushinski J.F.,
RA   Tucker P.W.;
RT   "Illegitimate recombination generates a class switch from C mu to C delta
RT   in an IgD-secreting plasmacytoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:4164-4168(1984).
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DR   PIR; A02033; HVMST7.
DR   AlphaFoldDB; P03980; -.
DR   SMR; P03980; -.
DR   MaxQB; P03980; -.
DR   PRIDE; P03980; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P03980; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW   Reference proteome; Signal.
FT   SIGNAL          1..20
FT   CHAIN           21..138
FT                   /note="Ig heavy chain V region TEPC 1017"
FT                   /id="PRO_0000015233"
FT   REGION          21..49
FT                   /note="Framework-1"
FT   REGION          50..54
FT                   /note="Complementarity-determining-1"
FT   REGION          55..68
FT                   /note="Framework-2"
FT   REGION          69..85
FT                   /note="Complementarity-determining-2"
FT   REGION          86..117
FT                   /note="Framework-3"
FT   REGION          118..127
FT                   /note="Complementarity-determining-3"
FT   REGION          128..138
FT                   /note="Framework-4"
FT   DISULFID        41..115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         138
SQ   SEQUENCE   138 AA;  15576 MW;  748157E4C6907B8E CRC64;
     MGWSYIILFL VATATDVHSQ VQLQQPGAEL VKPGASVQLS CKASGHTFTN YWIHWVKQRP
     GQGLEWIGEI NPNDGRSNYN EKFKNKATLT VDKSSSTAYM QLSSLTPEEF AVYYCARSDG
     YYDWFVYWGQ GTLVTFSA