ID   HVM54_MOUSE             Reviewed;         117 AA.
AC   P18525;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Ig heavy chain V region 5-84;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/cJ;
RX   PubMed=2499654; DOI=10.1084/jem.169.6.2007;
RA   Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J.;
RT   "Early onset of somatic mutation in immunoglobulin VH genes during the
RT   primary immune response.";
RL   J. Exp. Med. 169:2007-2019(1989).
CC   -!- MISCELLANEOUS: This sequence belongs to the VH7183 subfamily.
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DR   PIR; JT0505; HVMS84.
DR   PDB; 1AR1; X-ray; 2.70 A; D=-.
DR   PDB; 1MQK; X-ray; 1.28 A; H=20-117.
DR   PDB; 3EHB; X-ray; 2.32 A; C=20-117.
DR   PDB; 3HB3; X-ray; 2.25 A; C=20-117.
DR   PDBsum; 1AR1; -.
DR   PDBsum; 1MQK; -.
DR   PDBsum; 3EHB; -.
DR   PDBsum; 3HB3; -.
DR   AlphaFoldDB; P18525; -.
DR   SMR; P18525; -.
DR   IntAct; P18525; 1.
DR   MaxQB; P18525; -.
DR   PeptideAtlas; P18525; -.
DR   PRIDE; P18525; -.
DR   EvolutionaryTrace; P18525; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P18525; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT   CHAIN           20..117
FT                   /note="Ig heavy chain V region 5-84"
FT                   /id="PRO_0000015237"
FT   REGION          20..49
FT                   /note="Framework-1"
FT   REGION          50..54
FT                   /note="Complementarity-determining-1"
FT   REGION          55..68
FT                   /note="Framework-2"
FT   REGION          69..85
FT                   /note="Complementarity-determining-2"
FT   REGION          86..117
FT                   /note="Framework-3"
FT   DISULFID        41..115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         117
FT   STRAND          22..26
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   STRAND          29..31
FT                   /evidence="ECO:0007829|PDB:3EHB"
FT   STRAND          37..46
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   HELIX           48..50
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   STRAND          53..58
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   STRAND          64..70
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   STRAND          72..75
FT                   /evidence="ECO:0007829|PDB:3HB3"
FT   TURN            81..83
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   STRAND          87..92
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   HELIX           93..95
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   STRAND          97..102
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   HELIX           107..109
FT                   /evidence="ECO:0007829|PDB:1MQK"
FT   STRAND          111..117
FT                   /evidence="ECO:0007829|PDB:1MQK"
SQ   SEQUENCE   117 AA;  12872 MW;  234055CB6A469861 CRC64;
     MNFGLSLIFL VLVLKGVLCE VKLVESGGGL VQPGGSLKLS CAASGFTFSS YTMSWVRQTP
     EKRLEWVAYI SNGGGSTYYP DTVKGRFTIS RDNAKNNLYL QMSSLKSEDT AMYYCAR