HVM56_MOUSE
ID HVM56_MOUSE Reviewed; 97 AA.
AC P18527;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Ig heavy chain V region 914;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/cJ;
RX PubMed=2499654; DOI=10.1084/jem.169.6.2007;
RA Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J.;
RT "Early onset of somatic mutation in immunoglobulin VH genes during the
RT primary immune response.";
RL J. Exp. Med. 169:2007-2019(1989).
CC -!- MISCELLANEOUS: This sequence belongs to the VH7183 subfamily.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; JT0504; HVMS91.
DR PDB; 2DQT; X-ray; 1.80 A; H=1-97.
DR PDB; 2DQU; X-ray; 1.70 A; H=1-97.
DR PDB; 2DTM; X-ray; 2.25 A; H=1-97.
DR PDB; 3AB0; X-ray; 3.09 A; B/E=1-97.
DR PDBsum; 2DQT; -.
DR PDBsum; 2DQU; -.
DR PDBsum; 2DTM; -.
DR PDBsum; 3AB0; -.
DR AlphaFoldDB; P18527; -.
DR SMR; P18527; -.
DR MaxQB; P18527; -.
DR PRIDE; P18527; -.
DR EvolutionaryTrace; P18527; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P18527; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Immunity; Immunoglobulin;
KW Reference proteome.
FT CHAIN 1..>97
FT /note="Ig heavy chain V region 914"
FT /id="PRO_0000059899"
FT DOMAIN 1..>97
FT /note="Ig-like"
FT NON_TER 97
FT STRAND 3..7
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 10..12
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 18..27
FT /evidence="ECO:0007829|PDB:2DQU"
FT HELIX 29..31
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 32..39
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:2DQU"
FT HELIX 61..63
FT /evidence="ECO:0007829|PDB:2DQU"
FT TURN 64..66
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:2DQU"
FT TURN 73..76
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 77..82
FT /evidence="ECO:0007829|PDB:2DQU"
FT HELIX 87..89
FT /evidence="ECO:0007829|PDB:2DQU"
FT STRAND 91..97
FT /evidence="ECO:0007829|PDB:2DQU"
SQ SEQUENCE 97 AA; 10661 MW; C23CB33FF55DA893 CRC64;
EVKLVESGGG LVKPGGSLKL SCAASGFTFS SYAMSWVRQT PEKRLEWVAS ISSGGSTYYP
DSVKGRFTIS RDNARNILYL QMSSLRSEDT AMYYCAR
