HVM60_MOUSE
ID HVM60_MOUSE Reviewed; 116 AA.
AC P18531;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Ig heavy chain V region 3-6;
DE AltName: Full=Ig heavy chain V region M315;
DE Flags: Precursor;
GN Name=Ighv3-6; Synonyms=Gm16932;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/cJ;
RX PubMed=2499654; DOI=10.1084/jem.169.6.2007;
RA Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J.;
RT "Early onset of somatic mutation in immunoglobulin VH genes during the
RT primary immune response.";
RL J. Exp. Med. 169:2007-2019(1989).
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DR PIR; JT0509; HVMS31.
DR PDB; 1EZV; X-ray; 2.30 A; X=20-116.
DR PDB; 2IBZ; X-ray; 2.30 A; X=20-116.
DR PDBsum; 1EZV; -.
DR PDBsum; 2IBZ; -.
DR AlphaFoldDB; P18531; -.
DR SMR; P18531; -.
DR MaxQB; P18531; -.
DR PRIDE; P18531; -.
DR ProteomicsDB; 266924; -.
DR Ensembl; ENSMUST00000195124; ENSMUSP00000141343; ENSMUSG00000076672.
DR MGI; MGI:4439856; Ighv3-6.
DR VEuPathDB; HostDB:ENSMUSG00000076672; -.
DR GeneTree; ENSGT01030000234536; -.
DR InParanoid; P18531; -.
DR OMA; ATYHCAR; -.
DR Reactome; R-MMU-166663; Initial triggering of complement.
DR Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-MMU-2029481; FCGR activation.
DR Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR Reactome; R-MMU-977606; Regulation of Complement cascade.
DR Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR EvolutionaryTrace; P18531; -.
DR PRO; PR:P18531; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P18531; protein.
DR Bgee; ENSMUSG00000076672; Expressed in jejunum and 28 other tissues.
DR ExpressionAtlas; P18531; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW Reference proteome; Signal.
FT SIGNAL 1..18
FT CHAIN 19..116
FT /note="Ig heavy chain V region 3-6"
FT /id="PRO_0000015241"
FT REGION 19..48
FT /note="Framework-1"
FT REGION 49..53
FT /note="Complementarity-determining-1"
FT REGION 54..67
FT /note="Framework-2"
FT REGION 68..84
FT /note="Complementarity-determining-2"
FT REGION 85..116
FT /note="Framework-3"
FT DISULFID 40..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 116
FT STRAND 21..26
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 28..30
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 36..45
FT /evidence="ECO:0007829|PDB:1EZV"
FT TURN 47..49
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 50..58
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 64..73
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:1EZV"
FT TURN 80..85
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 89..91
FT /evidence="ECO:0007829|PDB:1EZV"
FT TURN 92..95
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 96..101
FT /evidence="ECO:0007829|PDB:1EZV"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:1EZV"
FT STRAND 110..116
FT /evidence="ECO:0007829|PDB:1EZV"
SQ SEQUENCE 116 AA; 13095 MW; 4562E03E53DC9E10 CRC64;
MKVLSLLYLL TAIPGILSDV QLQESGPGLV KPSQSLSLTC SVTGYSITSG YYWNWIRQFP
GNKLEWMGYI SYDGSNNYNP SLKNRISITR DTSKNQFFLK LNSVTTEDTA TYYCAR
