HVM61_MOUSE
ID HVM61_MOUSE Reviewed; 116 AA.
AC P18532;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Ig heavy chain V region 1B43;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/cJ;
RX PubMed=2499654; DOI=10.1084/jem.169.6.2007;
RA Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J.;
RT "Early onset of somatic mutation in immunoglobulin VH genes during the
RT primary immune response.";
RL J. Exp. Med. 169:2007-2019(1989).
CC -!- MISCELLANEOUS: This sequence belongs to the VH3660 subfamily.
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DR PIR; JT0508; HVMS1B.
DR PDB; 1KCS; X-ray; 2.50 A; H=22-116.
DR PDB; 1KCV; X-ray; 1.80 A; H=22-116.
DR PDB; 2F58; X-ray; 2.80 A; H=19-116.
DR PDB; 3F58; X-ray; 2.80 A; H=19-116.
DR PDBsum; 1KCS; -.
DR PDBsum; 1KCV; -.
DR PDBsum; 2F58; -.
DR PDBsum; 3F58; -.
DR AlphaFoldDB; P18532; -.
DR SMR; P18532; -.
DR PRIDE; P18532; -.
DR EvolutionaryTrace; P18532; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P18532; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW Reference proteome; Signal.
FT SIGNAL 1..18
FT CHAIN 19..116
FT /note="Ig heavy chain V region 1B43"
FT /id="PRO_0000015242"
FT REGION 19..48
FT /note="Framework-1"
FT REGION 49..53
FT /note="Complementarity-determining-1"
FT REGION 54..67
FT /note="Framework-2"
FT REGION 68..84
FT /note="Complementarity-determining-2"
FT REGION 85..116
FT /note="Framework-3"
FT DISULFID 40..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 116
FT STRAND 21..25
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 28..30
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 36..45
FT /evidence="ECO:0007829|PDB:1KCV"
FT TURN 47..49
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 50..58
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 64..71
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:1KCV"
FT TURN 80..85
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 86..91
FT /evidence="ECO:0007829|PDB:1KCV"
FT TURN 92..95
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 96..101
FT /evidence="ECO:0007829|PDB:1KCV"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:1KCV"
FT STRAND 110..116
FT /evidence="ECO:0007829|PDB:1KCV"
SQ SEQUENCE 116 AA; 13158 MW; 1CB547253681FF74 CRC64;
MRVLILLCLF TAFPGILSDV QLQESGPDLV KPSQSLSLTC TVTGYSITSG YSWHWIRQFP
GNKLEWMGYI HYSGNTSYNP SLKSRISITR DTSKNQFFLQ LNSVTTEDTA TYYCAR
