ID   HVM62_MOUSE             Reviewed;         117 AA.
AC   P18533;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Immunoglobulin heavy variable 3-5 {ECO:0000312|MGI:MGI:3648045};
DE   AltName: Full=Ig heavy chain V region 733 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=Ighv3-5 {ECO:0000312|MGI:MGI:3648045};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/cJ;
RX   PubMed=2499654; DOI=10.1084/jem.169.6.2007;
RA   Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J.;
RT   "Early onset of somatic mutation in immunoglobulin VH genes during the
RT   primary immune response.";
RL   J. Exp. Med. 169:2007-2019(1989).
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DR   PIR; JT0510; HVMS73.
DR   AlphaFoldDB; P18533; -.
DR   SMR; P18533; -.
DR   PRIDE; P18533; -.
DR   MGI; MGI:3648045; Ighv3-5.
DR   InParanoid; P18533; -.
DR   Reactome; R-MMU-166663; Initial triggering of complement.
DR   Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR   Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR   Reactome; R-MMU-2029481; FCGR activation.
DR   Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR   Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR   Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR   Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR   Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR   Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR   Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR   Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR   Reactome; R-MMU-977606; Regulation of Complement cascade.
DR   Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   PRO; PR:P18533; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P18533; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin;
KW   Immunoglobulin domain; Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..117
FT                   /note="Immunoglobulin heavy variable 3-5"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000015243"
FT   DOMAIN          19..>117
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        40..115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         117
SQ   SEQUENCE   117 AA;  13223 MW;  1595517827F976BE CRC64;
     MKMFTLLYLL TVVPGILSDV QLQESGPGLV KPSQSIALTC TVTGISITTG NYRWSWIRQF
     PGNKLEWIGY IYYSAITSYN PSPKSRTTIT RDTSKNQFFL EMNSLTAEDT ATYYCAR