HVM63_MOUSE
ID HVM63_MOUSE Reviewed; 237 AA.
AC P84751;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Ig heavy chain Mem5;
DE Flags: Fragment;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABB81885.1}
RP PROTEIN SEQUENCE OF 1-19, NUCLEOTIDE SEQUENCE [MRNA] OF 20-237, AND
RP FUNCTION.
RC STRAIN=BALB/cJ {ECO:0000312|EMBL:ABB81885.1};
RX PubMed=12414967; DOI=10.1128/jvi.76.23.12274-12280.2002;
RA Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T.,
RA Laver W.G., Bochkarev A., Zlotnick A., Air G.M.;
RT "Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus
RT (A/Memphis/31/98).";
RL J. Virol. 76:12274-12280(2002).
CC -!- FUNCTION: Anti-influenza H3N2 neuraminidase antibody.
CC {ECO:0000269|PubMed:12414967}.
CC -!- SUBCELLULAR LOCATION: Secreted.
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DR EMBL; DQ220746; ABB81885.1; -; mRNA.
DR PDB; 1ZAN; X-ray; 1.70 A; H=2-220.
DR PDB; 2ADF; X-ray; 1.90 A; H=108-220.
DR PDB; 2AEP; X-ray; 2.10 A; H=1-217.
DR PDB; 2AEQ; X-ray; 3.00 A; H=1-217.
DR PDB; 2G2R; X-ray; 2.75 A; B/H=109-221.
DR PDB; 2G5B; X-ray; 2.30 A; F=1-219.
DR PDB; 3BKC; X-ray; 1.90 A; H=92-227.
DR PDB; 3BKJ; X-ray; 1.59 A; H=92-220.
DR PDB; 3BKM; X-ray; 1.60 A; H=92-220.
DR PDB; 4HDI; X-ray; 2.45 A; B/H=2-220.
DR PDBsum; 1ZAN; -.
DR PDBsum; 2ADF; -.
DR PDBsum; 2AEP; -.
DR PDBsum; 2AEQ; -.
DR PDBsum; 2G2R; -.
DR PDBsum; 2G5B; -.
DR PDBsum; 3BKC; -.
DR PDBsum; 3BKJ; -.
DR PDBsum; 3BKM; -.
DR PDBsum; 4HDI; -.
DR AlphaFoldDB; P84751; -.
DR SMR; P84751; -.
DR MaxQB; P84751; -.
DR PeptideAtlas; P84751; -.
DR PRIDE; P84751; -.
DR EvolutionaryTrace; P84751; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P84751; protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Direct protein sequencing; Disulfide bond;
KW Immunity; Immunoglobulin; Reference proteome; Repeat; Secreted.
FT CHAIN 1..>237
FT /note="Ig heavy chain Mem5"
FT /id="PRO_0000059901"
FT DOMAIN 1..119
FT /note="Ig-like 1"
FT /evidence="ECO:0000255"
FT DOMAIN 126..218
FT /note="Ig-like 2"
FT /evidence="ECO:0000255"
FT REGION 101..105
FT /note="D segment"
FT /evidence="ECO:0000250|UniProtKB:P01783"
FT REGION 106..120
FT /note="JH2 segment"
FT /evidence="ECO:0000303|PubMed:12414967"
FT DISULFID 22..98
FT /evidence="ECO:0000250|UniProtKB:P01783,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 135
FT /note="Interchain (with a light chain)"
FT /evidence="ECO:0000250|UniProtKB:P01863,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 147..202
FT /evidence="ECO:0000250|UniProtKB:P01863,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 227
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000250|UniProtKB:P01863,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 230
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000250|UniProtKB:P01863,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 232
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000250|UniProtKB:P01863,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 237
FT /evidence="ECO:0000312|EMBL:ABB81885.1"
FT STRAND 3..7
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 10..12
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 18..27
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 29..31
FT /evidence="ECO:0007829|PDB:1ZAN"
FT STRAND 33..40
FT /evidence="ECO:0007829|PDB:3BKJ"
FT TURN 41..43
FT /evidence="ECO:0007829|PDB:2G2R"
FT STRAND 46..51
FT /evidence="ECO:0007829|PDB:3BKJ"
FT TURN 54..56
FT /evidence="ECO:0007829|PDB:2ADF"
FT STRAND 60..62
FT /evidence="ECO:0007829|PDB:1ZAN"
FT TURN 64..66
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 67..69
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 76..78
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 80..85
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 90..92
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 94..103
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 104..106
FT /evidence="ECO:0007829|PDB:1ZAN"
FT STRAND 108..110
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 114..118
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 127..131
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 135..138
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 139..155
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 158..161
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 162..164
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 170..172
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 176..178
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 181..191
FT /evidence="ECO:0007829|PDB:3BKJ"
FT TURN 192..197
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 201..206
FT /evidence="ECO:0007829|PDB:3BKJ"
FT HELIX 207..209
FT /evidence="ECO:0007829|PDB:3BKJ"
FT STRAND 211..216
FT /evidence="ECO:0007829|PDB:3BKJ"
SQ SEQUENCE 237 AA; 25350 MW; 6BFABA1E6F835C10 CRC64;
EVKLVESGGG LVQPGGSLSL SCATSGFTFI DYYMSWFRQP PGKALEWLGL IRNKGNGYTM
EYSASLKGRF TISRDNSQSI VYLHMNTLTA EDSATYYCAR VDYGTNYDYW GQGTTLTVSS
AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV HTFPAVLQSD
LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR GPTIKPCPPC KCPAPNS
